SLN BRAIN TARGETING DRUG DELIVERY FOR CNS: A NOVEL APPROACH
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 9
Abstract
The brain is a delicate organ and nature has very efficiently protected it. Brain is protected by presence of two barrier systems BBB (Blood Brain Barrier) and BCSFB (Blood Cerebrospinal Fluid Barrier) from very harmful materials. Despite aggressive research, patients suffering from fatal or debilitatingcentral nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, clinical failure of it restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in pharmacological treatment of CNS disorders. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, pro-drugs, chemical mediated, carrier-mediated, vector mediated and intranasal mediated drug delivery. ‘SLN technology based therapy’ made available a novel and sound platform for therapeutics. Solid lipid nanoparticles (SLNs) are structured for a novel system to provide drugs for removal of unwanted actions by modified formulations and for organ/cell targeting of moieties. Appropriate analytical techniques for the characterization of SLN is described hear. This article contains method of preparation, utilization of excipients(s), uses and highlighting of various approaches and meritsof SLN for brain targeting drug delivery as colloidal drug carriers.
Authors and Affiliations
Nitin Mori, Navin Sheth, Vishal Mendapara, Kalpesh Ashara, Jalpa Paun
SHANKA PUSPHPI: A SHORT REVIEW
Shanka pusphi is a natural product. Shanka pushpi is indicated as Medhya (brain tonic), digestive, appetite stimulant and carminative for digestive system. It has cardio-protective, heart strengthener and controls hypert...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES ON STEM OF STACHYTARPHETA JAMAICENSIS (L) VAHL.
The present study reveals the pharmacognostical and preliminary phytochemical studies of Stachytarphyta jamaicensis (L) Vahl. The objective of the present work comprises of collection, identification, macroscopical, micr...
MERCURY TOXICITY AND ITS MANAGEMENT
Mercury is an element that has been known for at least 4000 years (Chang 1985). It is a metal that is liquid at room temperatures and is widely used in our modern society. Today, the unique chemical and physical properti...
ISOLATION AND CHARACTERIZATION OF MURRAYA PANICULATA ETHANOL SEED EXTRACT FOR THEIR ANTIOXIDANT COMPONENTS
The objective of this study is isolation and characterization of Murraya paniculata ethanol seed extract for their antioxidant components. The 50 % ethanol seed extract of Murraya paniculata was screened for phytochemica...
FORMULATION AND EVALUATION OF SULPHASALAZINE INJECTION MADE BY MIXED SOLVENCY SOLUBILIZATION TECHNIQUE
Sulfasalazine, a sulfonamide derivative, is used as an antimicrobial agent by inhibiting bacterial growth and activity mainly in the treatment of ulcerative colitis and in the treatment of rheumatoid arthritis. It is pra...