SLN BRAIN TARGETING DRUG DELIVERY FOR CNS: A NOVEL APPROACH
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 9
Abstract
The brain is a delicate organ and nature has very efficiently protected it. Brain is protected by presence of two barrier systems BBB (Blood Brain Barrier) and BCSFB (Blood Cerebrospinal Fluid Barrier) from very harmful materials. Despite aggressive research, patients suffering from fatal or debilitatingcentral nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, clinical failure of it restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in pharmacological treatment of CNS disorders. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, pro-drugs, chemical mediated, carrier-mediated, vector mediated and intranasal mediated drug delivery. ‘SLN technology based therapy’ made available a novel and sound platform for therapeutics. Solid lipid nanoparticles (SLNs) are structured for a novel system to provide drugs for removal of unwanted actions by modified formulations and for organ/cell targeting of moieties. Appropriate analytical techniques for the characterization of SLN is described hear. This article contains method of preparation, utilization of excipients(s), uses and highlighting of various approaches and meritsof SLN for brain targeting drug delivery as colloidal drug carriers.
Authors and Affiliations
Nitin Mori, Navin Sheth, Vishal Mendapara, Kalpesh Ashara, Jalpa Paun
Keywords
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