Soft-tissue response to synthetic polymer implants made of cross-linked polyurethane and containing a biologically active substance, albucid or dacarbazine, in animals
Journal Title: Офтальмологический журнал - Year 2018, Vol 0, Issue 6
Abstract
Background: It is an urgent task of the today’s science to search for and introduce biointegrable synthetic materials into medical practice. Purpose: To investigate the soft tissue response to the polymer sample implants made of cross-linked polyurethane with an immobilized biologically active substance, albucid or dacarbazine, in animals. Materials and Methods: Thirty Wistar rats were used to assess the soft tissue response to polymer sample implants under examination. The cross-linked polyurethane-based sample implants with an immobilized biologically active substance, albucid or dacarbazine, were used in the experimental study. Results: The development of the connective tissue capsule around the sample implant, with the capsule completely separating the implant from the surrounding host tissue, was observed at the early time points. Sample implant porosity contributed to cell migration and gradual ingrowth of tissue structures into the implants, which prevented fast implant resorption, and was indicative of the implant biocompatibility with the host tissues. The placement of albucid-containing polyurethane implants in experimental animals resulted in the surrounding host tissue responses typical of aseptic inflammation. The placement of the dacarbazine-containing polyurethane implant in the back of each animal resulted in apparent changes in surrounding host tissue typical for the inflammatory process. It is likely that dacarbazine from the dacarbazine-containing polyurethane sample implant was durably released in the host tissues surrounding the sample, and exerted some biologically active effect which resulted in persistent inflammation at the site of implantation. Conclusion: The albucid- and dacarbazine-containing polymer materials obtained seem promising, and might be widely used as soft tissue substitutes in restorative and reconstructive eye and maxillofacial surgery.
Authors and Affiliations
N. A. Galatenko, D. Kulyesh, A. Maletskyi, O. Karpenko
Keywords
Related Articles
- EP ID EP432292
- DOI 10.31288/oftalmolzh201865258
- Views 69
- Downloads 0
Severe corneal infections induced by contact lens wearing
Background. Over the recent years, a lot of authors have noticed changes in risk factors of microbial keratitis development as well as in variety of agents inducing them. Soft contact lens wearing has been reported to be...
Retinal structural changes in patients with Alzheimer's disease
Background: Retinal disorders in patients with Alzheimer's disease (AD) are given special attention. Purpose: To identify optical coherence tomography (OCT)-based retinal structural changes in patients with mild or mode...
Mathematical analysis of the effect of Pro72Arg polymorphism in the TP53 gene on the emergence and progression of POAG
Background: Elevated intraocular pressure (IOP) is a major risk factor for primary open-angle glaucoma (POAG). Increased attention is also given to activation of apoptosis of retinal ganglion cells which results in the d...
Interrelationship of corneoscleral rigidity, corneal thickness and target IOP levels in patients with unstabilized POAG
Background: To the best of our knowledge, no strict criteria for estimating the probability of glaucomatous progression have been reported. Purpose: To investigate the interrelationship between corneoscleral rigidity, c...
Prevalence of ocular diseases in patients with pulmonary tuberculosis and HIV infection
Background: Given the high prevalence and rate of disability from ocular pathologies, it is clinically and socially important to determine their prevalence in patients with tuberculosis and HIV infection. Purpose: To det...