Soft Tissue Sarcoma; Management and Treatment Outcome in a Tertiary Health Institution in Northern Nigeria
Journal Title: INNOVATIVE JOURNAL OF MEDICAL AND HEALTH SCIENCE - Year 2018, Vol 8, Issue 5
Abstract
Soft tissue sarcoma constitutes 7% of all cancers in Nigeria. A complete staging of this tumour is important to evaluate the prognosis and plan the treatment in a multidisciplinary team. Management of sarcoma includes surgery, which involve partial or complete excision of the tumour mass. Surgery is the primary treatment modality for soft tissue sarcoma. Radiotherapy is useful in both localized and metastatic disease. Reports have shown the benefit of radiation therapy in decreasing recurrence rate in positive margin post excision. It is also useful for palliation of some symptoms. Chemotherapy has been shown to improve the survival of patients. Doxorubicin and Ifosfamide have shown better response in patients with these malignancies. The outcome of patients with soft tissue sarcoma depends on the margins’ status post excision, performance status, grade, and stage of the disease. MATERIALS AND METHODS It is a five year retrospective study of patients with soft tissue sarcoma seen in the department of radiotherapy and Oncology, Usmanu Danfodiyo University teaching hospital. The treatment and overall survival at one year post diagnosis were reviewed with associating compounding variable. RESULTS A total of 123 patients were reviewed, out of which 69.9% of the patients had radiotherapy, and 64% of the patients who had radiotherapy received palliative dose. The commonest chemotherapy used was vincristine, which was used in 82% of the patients who had chemotherapy, while 76% received doxorubicin and 10% had ifosfamide. The overall survival at one year was assessed in 112 patients. There was no significant difference between their age, gender, histological type and their survival at one year, however there was an association between the performance status (ECOG) and surgical excision status. CONCLUSION The outcome of patients with soft tissue sarcoma after diagnosis is determined by the performance status and the surgical excision margin. This will ultimately guide treatment of these groups of malignancies.
Authors and Affiliations
Usman Malami Aliyu, Ibrahim Hassan, Bello Basheer, Ehiosa Charles Okuofo, Charles Oluchukwu Okwonna
Keywords
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- EP ID EP318583
- DOI 10.15520/ijmhs.v8i5.2144
- Views 68
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