Solanum macrocarpon Leaf Extract Effects on Cerebral Cortex Microanatomy in Isoproterenol Induced Myocardial Infarction
Journal Title: Journal of Complementary and Alternative Medical Research - Year 2016, Vol 1, Issue 1
Abstract
Solanum macrocarpon is a plant with edible fruit and its potentials as a medicinal herb have also been investigated. Its leaf extract had been suggested to have effects that could ameliorate myocardial infarction. In the current investigation, S. macrocarpon leaf aqueous extract effects on the brain tissue was observed when it is being used to ameliorate induced myocardial infarction; because its effects on the brain was also considered to be very important so as to investigate the safety of its use on brain health. Thirty adult male Wistar rats were divided into five groups of six rats each; Group A served as control and were only fed ad libitum and administered placebo. Group B rats were animals that suffered induced myocardial infarction but did not receive any therapeutic intervention. Group C received 100 mg/kg of S. macrocarpon aqueous leaf extract; Group D received 200 mg/kg body weight of S. macrocarpon leaf extract while Group E received 400 mg/kg body weight. The regimen was also to assess the effects of variations in dosages. Experiment lasted for 28 days and the animals were sacrificed by cervical dislocation. Brain tissues were excised and fixed in formal saline; then processed using the Haematoxylin and Eosin method. Specific effects of S. macrocarpon include alterations of cell morphologies and loss of cells at the higher doses. There were also evidences of alterations of the cerebral histoarchitecture and the neuropil. Results showed that the extract at all dosages had deleterious effects on the brain tissue and the gravity of effects increased with the dosage.
Authors and Affiliations
J. O. Owolabi, S. Y. Olatunji, A. J. Olanrewaju
Keywords
Related Articles
- EP ID EP350607
- DOI 10.9734/JOCAMR/2016/26867
- Views 42
- Downloads 0
Phytochemical and Nutritional Evaluation of Southeastern Nigerian Grown Moringa oleifera Leaf Extract
Herbal medicine is based on the premise that plants contain natural substances that can promote health and alleviate illnesses. The plant kingdom represents a rich store house of organic compounds, many of which have bee...
In vitro Screening of the Leaf Extracts from Gardenia ternifolia (Forest Gardenia) for their Anticancer Activity
Aim: The aim of the study is to evaluate the cytotoxicity of the crude extracts of Gardenia ternifolia (Oliv.) in human prostate cancer (PC-3) and breast cancer (MCF-7) cell lines. Study Design: Successive extractions of...
GC-MS Analysis of Methanolic Extracts of Leaf and Stem of Marsilea minuta (Linn.)
Aims: To analyze the chemicals composition of methanolic extracts of leaf and stem of M. minuta collected from Uppur Village, Tamilnadu, India by GC-MS. Study Design: Experimental study. Methodology: The Methanolic extra...
Antibiotics Susceptibility Study of Uropathogens Isolated from Asymptomatic Pregnant Women Attending a Tertiary Maternity Clinic in
Background: Urinary tract infection (UTI) is one of the commonest infections during pregnancy and results in perinatal and maternal morbidity and mortality. For bacterial UTIs, the causative agents have remained virtuall...
Conservation Status of Animal Species Used by Indigenous Traditional Medicine Practitioners in Ogbomoso, Oyo State
Aim: To document the indigenous knowledge of fauna species used in traditional medicine practices and to establish their conservational status. Study Design: A questionnaire guided survey of the traditional uses of faun...