Solid Malignant Tumors of Infancy and Childhood: A Histopathological Study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 1
Abstract
In general, the features of malignancies in children differ biologically and histologically from those of adults with respect to incidence, type of tumor, underlying familial or genetic aberration and Tendency to regress spontaneously or cytodifferantiate. In recent years, identification of specific genes, oncogenes, tumor markers and other biological and pathological factors have played an important role in staging and classifying risk categorization of specific tumors as low, intermediate and high-risk lesions. Hence there is need for accurate histopathological reporting in conjugation with ancillary methods. This study was under taken to evaluate the incidence and morphological features of solid malignant tumors in children of fifteen years and below. The material for present study was obtained from SIMS and referred cases. The histopathology slides and paraffin blocks were reviewed. The sections 3-5 μ thick, were cut and stained by haematoxylin and eosin in all cases and special stains like PAS, MTS, RT and IHC done where ever feasible. An analysis of 66 cases of solid malignant tumors of childhood over a period of 5years were made.The early onset and the embryonal nature of the major paediatric tumors, suggest a prenatal origin and role of genetic factors. Infections, exposure to drugs and chemicals during pregnancy are other contributory factors. Accurate incidence of data is important in the planning and evaluation of clinical trials. Documentation of cases, advanced diagnostic methods like IHC, cytogenetic studies and treatment modalities with close follow up is needed to achieve better statistical evaluation of the problem.
Authors and Affiliations
Chandrashekhar Thotadamane Nagaraja, Ravindra Basagouda Patil, Geethalakshmi Ugrappa, Rameshbabu Krishnamurthy
Keywords
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