SOLUBILITY AND DISSOLUTION PROFILE STUDIES OF GLICLAZIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
This study describes the solubility and dissolution profile of Gliclazide. The solubility study was evaluated by using the shake flask method. The dissolution study has been carried out in different buffers for Gliclazide solid dosage form and estimated by using the RP-HPLC technique. In the present study a dissolution medium was developed and selected on the basis of solubility data of Gliclazide at 37 °C. The solubility data revealed that pH 7.4 phosphate buffer (0.6375 mg/ml) shall be suitable dissolution medium. The discriminating power of the selected dissolution medium relative to the other dissolution medium was evaluated. The described method can be successfully applied for the analysis of tablets, active pharmaceutical ingredient and drug dissolution studies.
Authors and Affiliations
Narasimha Swamy , Nishant Goswami
Keywords
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