SOLUBILITY AND DISSOLUTION PROFILE STUDIES OF GLICLAZIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6

Abstract

This study describes the solubility and dissolution profile of Gliclazide. The solubility study was evaluated by using the shake flask method. The dissolution study has been carried out in different buffers for Gliclazide solid dosage form and estimated by using the RP-HPLC technique. In the present study a dissolution medium was developed and selected on the basis of solubility data of Gliclazide at 37 °C. The solubility data revealed that pH 7.4 phosphate buffer (0.6375 mg/ml) shall be suitable dissolution medium. The discriminating power of the selected dissolution medium relative to the other dissolution medium was evaluated. The described method can be successfully applied for the analysis of tablets, active pharmaceutical ingredient and drug dissolution studies. 

Authors and Affiliations

Narasimha Swamy , Nishant Goswami

Keywords

Related Articles

ROLE OF NATURAL POLYMERS IN SUSTAINED RELEASE DRUG DELIVERY SYSTEM: APPLICATIONS AND RECENT APPROACHES 

In recent years there have been important developments in different dosage forms for existing and newly designed drugs and natural products, and semi-synthetic as well as synthetic excipients often need to be used for a...

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE 

Prime object of present study was to develop and evaluate mucoadhesive tablets of Salbutamol Sulphate by non aqueous granulation of polymers HPMC K-4M (Hydroxypropyl Methyl Cellulose) and Chitosan in different ratios (1:...

A VALIDATED SIMULTANEOUS HPLC METHOD FOR DETERMINATION OF ASSAY OF TEMAZEPAM AND FORCED DEGRADATION STUDIES 

A new HPLC method was developed for selective and simultaneous determination of of Teamazepam. The developed method is also applicable for the related substances determination in bulk drugs. The chromatographic separatio...

PREPARATION AND IN-VITRO EVALUATION OF BACLOFEN LOADED MICROSPHERES 

The present study was aimed to prepare Baclofen microspheres for sustained release using various polymers such as ethyl cellulose (hydrophobic), hydroxy propyl methyl cellulose (hydrophilic) by employing solvent evaporat...

PULSATILE DRUG DELIVERY SYSTEMS USING NATURAL POLYMERS AS RELEASE MODIFIERS  

Sustained and controlled drug delivery system release the drug at a substantially steady rate of release per unit of time. However, there are instances where maintaining a constant blood level of a drug is not desirable....

Download PDF file
  • EP ID EP161187
  • DOI -
  • Views 88
  • Downloads 0

How To Cite

Narasimha Swamy, Nishant Goswami (2012). SOLUBILITY AND DISSOLUTION PROFILE STUDIES OF GLICLAZIDE IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC . International Research Journal of Pharmacy (IRJP), 3(6), 126-129. https://europub.co.uk/articles/-A-161187