SOLUBILITY ENHANCEMENT OF AMISULPRIDE BY SOLID DISPERSION TECHNIQUE AND PREPARATION OF FAST DISSOLVING TABLETS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Amisulpride exhibits anti-psychotic activities by selectively binding to dopamine D(2) and D(3) receptors in the limbic system. It is used in the treatment of psychoses, paranoid, productive schizophrenias, dysthymia. However, amisulpride (AMP) is poorly water soluble drug, so solubility is the main constraint for oral bioavailability. An attempt has been made to increase the solubility of this drug by formulating solid dispersion (SD) by using β-cyclodextrin (β-CD) employing spray drying method and then formulating fast dissolving tablets(FDT). Among the two different formulation of SD, formulation SD2 containing amisulpride & β-CD in the ratio of 1:2 gives best drug content and dissolution profile and among tablet formulations. FDTs were prepared by direct compression technique using superdisintegrants such as croscarmellose sodium and sodium starch glycolate in different concentrations. SDs were characterized by FT-IR, DSC analysis and evaluated for drug content and in vitro dissolution profiles. Tablet formulations were evaluated for pre compressional parameters such as angle of repose, bulk & tap density, Carr’s index, Hausner’s ratio and post compression parameters such as hardness, friability, weight variations, drug content, wetting time, disintegration time and in vitro dissolution profile. Formulation CF2 containing 6.5% croscarmellose sodium gives best disintegration and dissolution profile compared with other formulations. Results showed that β-cyclodextrin is a promising polymer for enhancing the solubility of AMP
Authors and Affiliations
Krishna. T Murali, Vivek Kumar A. Patel, Rajashekar Valluru, Dr. Jagadeesh G. Hiremath, D. Prathapreddy
Keywords
Related Articles
- EP ID EP222199
- DOI -
- Views 142
- Downloads 0
Recent Trends in Screening and Evaluation Methods of Anticancer Drugs
Cancer is one of the major life threatening diseases worldwide. The available anticancer drugs have distinct mechanisms of action which may vary in their effects on different types of normal and cancer cells. Screening m...
FORMULATION AND EVALUATION OF HERBAL BASED ANTI MICROBIAL CREAM USING COW GHEE AS BASE
Abstract Essential oils like eucalyptus and neem are well known for its anti microbial activity. The aim of this study is to evaluate the anti-bacterial activity of two essential oils (eucalyptus oil,neem oil)by incorpor...
Development and evaluation of Propranolol hydrochloride buccal mucoadhesive gel using Natural Mucoadhesive Agent obtained from the Fruits of Ficus carica L.
Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of drugs. The paper describes formulation of buccal mucoadhesive gel from Ficus carica mucilage using pror...
Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet
Amlodipine besylate is a recognized drug for hypertension therefore development of an ODT of Amlodipine besylate and to evaluate the effect of various superdisintegrants on its disintegration time and release profile was...
DESIGN AND IN VITRO CHARACTERIZATION OF KETOPROFEN CORE IN CUP PULSATILE TABLETS FOR CHRONOMODULATED DRUG THERAPY.
Abstract The aim of the present investigation is to intend, develop and evaluate a pulsatile drug delivery containing a core-in-cup based system of dry coated tablet of ketoprofen based on chronomodulated approach for ma...