Abstract

Candesartan cilexetil is a pro-drug w h i c h h a s p o o r bioavailability b e c a u s e o f p o o r s o l u b i l i t y as it belongsto BCS class II. The aim of study is to enhance the solubility of candesartan cilexetil by mixed solvency approach. Solution was made by using different cosolvents to enhance solubility of candesartan cilexetil. Polyethylene glycol,ethanol, Tween 20 were used as solvents to increase solubility of candesartan cilexetil. A mixture of ethanol, tween 20, PEG 200 (1:1:1) and water was selected for solubility enhancement of candesartan cilexetil. FTIR study did not show any interaction between drug and excipients. Box-Behnken design was used for optimization offormulation.The mixture of drug, PEG 200, tween 20 and water was evaluated for drug content,% transmittance, pH, visual clarity. When the level of ethanol, tween 20 or PEG increased, the %transmittance increased. The stability study up to one month showed that no significan changes by evaluation parameter. Thus by a p p l y i n g m i xe d s o l ve n cy a p p r o a ch to the candesartan cilexetil, solubility of candesartan cilexetil was increased thousand times as compared to drug alone.

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