Soluble transferrin receptor levels in obese and non obese adolescents
Journal Title: Paediatrica Indonesiana - Year 2014, Vol 54, Issue 2
Abstract
Background Iron deficiency in children and adolescents maybe dueto an inadequate supply of iron as well as increased iron requirementsfor growth and developmental processes. The incr easing prevalence ofobesity puts children at risk of iron deficiency. Studies on the effectsof obesity on iron deficiency have focused on low grade systemicinflammation as well as examining soluble transferrin receptor levels(sTfR) as an indicator ofiron deficiency.Objective To compare sT fR levels in obese and non-obeseadolescents, assess for correlations between BMI, sTfR and obesity,and determine the risk of iron deficiency in obese adolescents .Method T his cross sectional study was conducted on 20 obeseand 20 non-obese adolescents aged 15-17 in East Aceh District,from September to December 20 11. Subject were chosen throughcluster sampling. The obese subjects had BMI > 95th percentileand the non-obese subjects had BMI s:851h percentile based onthe 2000 National Center for Health Statistics (NCHS). Exclusioncriteria were blood disorders, chronic diseases, and a history ofbleeding. Data were analyzed by Chi-square test and T test witha significance level of P < 0.05, and Pearson's correlation.Results The mean s TfR levels in obese adolescents was higher thanin non-obese adolescents, [2.59 (SD 0.76) vs 2.14 (SD 0.45) μg/mL(P = 0.030)]. Iron deficiency (sTfR> 2.5 μgimL) was more commonin obese than in non-obese adolescents [ (55% vs . 15%, respectively,(P = 0.019) ]. Analysis of the relationship between obesity accordingto BMI andsTfRrevealedan OR of 6.93; 95% CI 1.53 to3 1.38. Ther elationship between the BMI and sTfR levels indicated a positive,moderate strength of association (r = 0.392) .Conclusion The mean sT fR levels in obese adolescents is significantlyhigher than in non-obese individuals. Obese adolescentshave a 6.93 times higher risk of iron deficiency than non-obeseadolescents. Body mass index has a positive and moderate associationwith sTfR.
Authors and Affiliations
Zul Febrianti, Fadil Oenzil, Firman Arbi, Gustina Lubis
Keywords
Related Articles
- EP ID EP458706
- DOI 10.14238/pi54.2.2014.77-81
- Views 95
- Downloads 0
Low birth weight profiles at H. Boejasin Hospital, South Borneo, Indonesia in 2010-2012
Background The prevalence of low birth weight (LBW) is still high in Indonesia. Intrauterine growth restriction (IUGR) and prematurity are the most frequent causes. Prematurity has higher mortality rate. Cultural diversi...
Risk factors of soil-transmitted helminth infection among elementary school students
Background Helminth infection remains a health problem, especially in school-aged children. Mass eradication programs with a single dose of anti-helminthic drugs were employed by the local government in some endemic area...
Selenium for acute watery diarrhea in children
Background Acute watery diarrhea remains a major health problem affecting infants and children in developing countries. Selenium deficiency may be a risk factor for diarrhea and vice versa. Few studies have been conducte...
Knowledge, attitude, and behavior of pregnant women on early initiation of breastfeeding
Background Infant mortality rate is an indicator of the degree ofhealth in society. In Indonesia, the infant mortality rate remainshigh, with most deaths occurring in the first 24 hours of life.Breastfeeding has been sho...
Mortality rates in pediatric septic shock
Background Septic shock remains a major cause of morbidity and mortality in children admitted to the intensive care unit. Recent investigations from developed countries have reported mortality rates of 20-30%. Few studie...