SOLUBLITY ENHANCEMENT OF FLUCONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined and ranged in between 5.1 to 10.9 and 6.1 to 7.1. Results showed that remarkable increase in aqueous solubility of Fluconazole in presence of large concentration of hydrotropes. Marketed fluconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error. Keywords: Solubility enhancement, hydrotropes, Solid dispersion
Authors and Affiliations
Anu Kaushik
Keywords
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