Solvent-free synthesis for imidazole-1-yl-acetic acid hydrochloride: an intermediate for zoledronic acid
Journal Title: Asian Journal of Green Chemistry - Year 2019, Vol 3, Issue 0
Abstract
A convenient and environmentally-friendly protocol for the preparation of imidazol-1-yl-acetic acid hydrochloride is described via solvent-free N-alkylation of imidazole by tert-butyl chloroacetate, the obtained imidazol-1-yl-acetic acid tert-butyl ester was hydrolyzed in water and treated with hydrochloric acid to get imidazol-1-yl-acetic acid hydrochloride in good yields. Unlike the previously reported methods, this two step process is completely free from the use of hazardous solvents, besides, it has high yielding and been characterized by simple and easy work-up procedure. Imidazol-1-yl-acetic acid hydrochloride produced by the described method is converted into zoledronic acid monohydrate of medicinal use.
Authors and Affiliations
Chandra Kant Belwal, Jaimin Patel
Keywords
Related Articles
- EP ID EP647219
- DOI 10.33945/SAMI/AJGC.2019.4.5
- Views 99
- Downloads 0
Biosorption of Fe (III) onto coffee and tea powder: Equilibrium and kinetic study
The coffee and tea powders were investigated to be as a novel low-cost non-conventional biosorbent for the removal of Fe (III) from aqueous solutions. Biosorption isotherms and kinetics were also assessed. The studied op...
Response surface methodology: photodegradation of methyl orange by CuO/ZnO under UV light irradiation
Zinc oxide (ZnO) and copper oxide doped zinc oxide photocatalysts (CuO/ZnO) were synthesized by precipitation method. The effect of CuO loading on the physicochemical properties and photocatalytic performance of ZnO in p...
Synergy of binary ionic liquids in a three component one-pot synthesis of 3,4,6-triarylpyridazine at ambient temperature
A mixture of two ionic liquids have been used for a green synthesis of 3,4,6-triarylpyridazine in high yield and at room temperature. The two ionic liquids acts in tandem. The advantage of this method is a room temperatu...
Silver functionalized on hydroxyapatite-core-shell magnetic γ-Fe2O3: An enviromentaly and readily recyclable nanatalyst for the one-pot synthesis of 14H-dibenzo[a,j]xanthenes derivatives
An efficient and simple procedure for the preparation of silver functionalized on hydroxyapatite-core-shell magnetic γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ag)as an enviromentaly efficient magnetically recoverable and reusab...
Ionic liquids (ILs): advances in biorefinery for the efficient conversion of lignocellulosic biomass
Lignocellulosic biomass contains polymers of cellulose, hemicellulose, and lignin, bound together in a complex structure. Many physicochemical structural and compositional factors hinder the hydrolysis of cellulose prese...