Some biochemical markers that can predict pre-eclampsia
Journal Title: Scientific Journal of Review - Year 2016, Vol 5, Issue 3
Abstract
TNF– α directly damages the vascular endothelial cells, reduces regional blood flow, causes occlusion of vessels and increases endothelial permeability. Endothelial cell injury after TNF– α mediated activation of immune system may result in secretion of vasoactive substances and increase in vascular permeability and intravascular coagulation. TNF-α may be involved in the pathogenesis of preeclampsia and may identify the patients who are at high risk of PE and can be a potential marker of the severity of the preeclamptic syndrome. Preeclamptic women had deranged lipid profile due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key role in the development of symptoms of Pre-eclampsia. Furthermore, changes to lipid metabolism may contribute towards the endothelial lesions observed in pre-eclampsia.
Authors and Affiliations
Mohammad Sayyed Bakheet*| Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Mohamed Ismail Seddik| Department of clinical pathology, Faculty of Medicine, Assuit University, Egypt., Abdelzaher| Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Mohammad Mohammad Abolfotoh| Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Abdelaziz Eldarwesh| Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Alomairi Mostafa| Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Maher Abdelshakor| Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
Keywords
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- EP ID EP228
- DOI 10.14196/sjr.v5i3.2156
- Views 614
- Downloads 84
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