Some of the effects of aqueous crude seed extract of datura stramonium on the histology of the frontal cortex and hippocampus of sprague dawley rats
Journal Title: Scientific Journal of Biological Sciences - Year 2012, Vol 1, Issue 2
Abstract
This study was carried out in order to investigate some of the effects of aqueous seed extract of Datura stramonium on the histology of the frontal cortex and hippocampus of Sprague Dawley rats as marker of toxicity. 16 adult male Sprague Dawley rats were used for this study. The rats were distributed into two groups (A and B). The rats in group B served as the treatment group and were administered with 300 mg/kg bwt of the aqueous seed extract of D. stramonium while the animals in group A which served as the control were administered with equal volume of phosphate buffered saline (PBS). The duration of administration was for fourteen days (14d). The rats were sacrificed using cervical decapacitation 3hrs after the last administration. The brains were excised from the skulls of the animals and were completely fixed in 10% formol calcium. 24 hours after fixation, the frontal cortices and the hippocampi were excised from the fixed brains and were processed for routine histological study using Hematoxylin and eosin (H&E) stains. Observations made from the permanent photomicrographs revealed alterations in the histoarchitecture of the frontal cortices and hippocampi of the rats. These findings provide evidence that suggest that the oral administration of aqueous seed extract of D. stramonium confers deleterious effects on the frontal cortices and hippocampi of Sprague Dawley rats.
Authors and Affiliations
A. D. Adedayo*| Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria, T. A. Adekilekun| Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Osun Nigeria
Keywords
Related Articles
- EP ID EP1065
- DOI -
- Views 663
- Downloads 43
Some biological aspect of carasobarbus luteus (Heckel, 1843) in hoor al-azim wetland
The Population Dynamics and status of Hemeri (Carasobarbus luteus) in Hoor Al-azim wetland (Khuzestan provinces, Iran) were investigated to derive information required for their management. During this study from 2011 to...
Recent progress in sustainable development and environmentally friendly energy systems: Case of Sudan
The move towards a low-carbon world, driven partly by climate science and partly by the business opportunities it offers, will need the promotion of environmentally friendly alternatives, if an acceptable stabilisation l...
Haematological effects of aqueous extract of Vernonia amygdalina in wistar rats
The present study assessed the haematological effects of aqueous extract of (Vernonia amygdalina) in wistar rats. Fifteen (15) adult Wistar rats were used in this study. The animals were divided into three groups of five...
In vitro antibacterial efficacy of crude ethanolic leaf extract and alkaloidal fractions of Phyllanthus amarus on uro-pathogens
The phytochemistry and in vitro antibacterial efficacy of crude ethanolic leaf extract and alkaloidal fractions of Phyllanthus amarus on the Gram positive (Streptococcus sp, Staphylococcus aureus; Coagulase negative Stap...
Effects of aqueous crude leaf extract of senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of male sprague dawley rats
Whenever any plant and/or herb is ingested, the body system interacts with it in an attempt to get rid of any harmful toxins such may contain, especially if the body cannot convert the foreign substance into useful compo...