Specific gene hypomethylation and cancer: new insights into coding region feature trends.
Journal Title: Bioinformation - Year 2009, Vol 3, Issue 8
Abstract
Giving coding region structural features a role in the hypomethylation of specific genes, the occurrence of G+C content, CpG islands, repeat and retrotransposable elements in demethylated genes related to cancer has been evaluated. A comparative analysis among different cancer types has also been performed. In this work, the inter-cancer coding region features comparative analysis carried out, show insights into what structural trends/patterns are present in the studied cancers.
MD simulation and experimental evidence for Mg binding at the b site in human AP endonuclease 1.
Apurinic/apyrimidinic endonuclease 1 (APE1), a central enzyme in the base excision repair pathway, cleaves damaged DNA in Mg(2+) dependent reaction. Despite characterization of nine X-ray crystallographic structures of h...
Welcome to "Bioinformation" a data journal.
Bioinformation describes the collection of biological data points on the molecular biology of cell structure, growth, development, differentiation, division and function. Collection of biological data points require simp...
The integrated web service and genome database for agricultural plants with biotechnology information.
The National Agricultural Biotechnology Information Center (NABIC) constructed an agricultural biology-based infrastructure and developed a Web based relational database for agricultural plants with biotechnology informa...
Insights from molecular modeling and dynamics simulation of pathogen resistance (R) protein from brinjal.
Resistance (R) protein recognizes molecular signature of pathogen infection and activates downstream hypersensitive response signalling in plants. R protein works as a molecular switch for pathogen defence signalling and...
Structural segments and residue propensities in protein-RNA interfaces: comparison with protein-protein and protein-DNA complexes.
The interface of a protein molecule that is involved in binding another protein, DNA or RNA has been characterized in terms of the number of unique secondary structural segments (SSSs), made up of stretches of helix, str...