Spectral correction for attenuating retroactivity in synthetic biology networks
Journal Title: International Journal of engineering Research and Applications - Year 2017, Vol 7, Issue 8
Abstract
The reliability of synthetic biology systems is challenged by the undesired retroactive signals transmitted by the downstream modules to the upstream modules. These retroactive signals modify the input and output signals of the system, limiting the predictability of the system. This is viewed as similar to the loading effect on electrical, mechanical or hydraulic systems and is being studied using the typical engineering strategies. Here, we propose spectral analysis as a tool to explore and propose methods to attenuate this phenomenon. We select an existing system constituted by an input protein, which phosphorylates another protein to form the output, which further binds to another module in the downstream. The input signal with downstream connection is spectrally decomposed to four key components. We report how the dynamics of the system varies for each of the four components and its combinations. Our results show that the removal of the first harmonic component of the retroactive input signal can attenuate the retroactive effect. The biological significance and wet lab protocols for achieving this spectral correction is to be investigated further.
Authors and Affiliations
Silpa Bhaskaran, Achuthsankar S. Nair
Keywords
Related Articles
- EP ID EP391954
- DOI 10.9790/9622-0708025965.
- Views 92
- Downloads 0
Voltammetric behavior of selenium from H2SeO3 solution on solid copper amalgam electrode
Issues concerning the remote monitoring and in-the-field analysis have generated considerable research effort aimed at finding methods with acceptable performance. Voltammetry has been known as one of the methods that ar...
Theoretical Calculation Of Surface Energy Of Anatase Tio2 (111) And Zro2(111): An Important Parameter For Osseointegration Of Dental Implants
The characteristics of the materials that are used for dental implants are critical for the success of the implant process. Surface energies of the materials that are used for implant surgery are especially important for...
Power Factor Correction and Speed Control of BLDC Motor Drive Fed by Zeta Converter
This paper proposes a brushless dc (BLDC) motor fed by zeta converter for power factor correction (PFC). A single phase supply followed by an uncontrolled bridge rectifier and a Zeta DC-DC converter is used to control th...
Predicting The Mode Of Transportation Using GPS Data, For Vehicular Carbon Footprint Determination
Greenhouse gas emissions by vehicles is damaging the environment. In order to take remedial measures at individual level, one must first know the full scale of damage being done. This study suggests that using GPS data f...
“Computer Aided 3-D Modeling and Design of Human Elbow Joint”
Man-made elbow or simulated elbow or built elbow is in the long run utilized when organic elbow can't work further. Such conditions are crack, contamination, joint pain, separation and tendonitis. In one of these conditi...