Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms
Journal Title: Bezmiâlem Science - Year 2021, Vol 9, Issue 1
Abstract
Objective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations. Methods: The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated. Results: Beer’s plots were obeyed in a general concentration range of 10-500 μg mL-1 and 20-600 μg mL-1 for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated. Conclusion: The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method.
Authors and Affiliations
Cem ÖNAL, Demet DİNÇEL
Keywords
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- EP ID EP691824
- DOI 10.14235/bas.galenos.2020.3916
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