SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE, LEVOCETIRIZINE DIHYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN TABLET DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 1
Abstract
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride in bulk and tablet dosage form. The method is based on the simultaneous equations for analysis of the three drugs using methanol as solvent. Ambroxol hydrochloride has absorbance maxima at 248 nm, levocetirizine dihydrochloride has absorbance maxima at 230 nm and phenylephrine hydrochloride has absorbance maxima at 217 nm in methanol. The linearity was obtained in the concentration range of 5-35 μg/ml, 4-28 μg/ml and 2-28 μg/ml for ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. The concentrations of the drugs were determined by using simultaneous equations at three wavelengths. The mean recovery was 101.41 ± 0.82, 99.09 ± 0.95 and 99.52 ± 1.59 for ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. The method was successfully applied to combined dosage form because no interference from the excipients was found. The suitability of this method for the quantitative determination of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride in combination. The results of analysis have been validated statistically and by recovery studies.
Authors and Affiliations
Rahul Ghodasara , Arun Prajapati
Keywords
Related Articles
- EP ID EP146078
- DOI -
- Views 98
- Downloads 0
SCAFFOLD: TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Scaffolds are the central components, which are used to deliver the cells, drug and gene into the body. Polymeric scaffolds may be prepared as typical 3-D porous matrix, nanofibrous matrix, thermo sensitive sol-gel trans...
FABRICATION OF PULSATILE DELIVERY MULTIPARTICULATE SYSTEM OF POORLY WATER SOLUBLE CARVEDILOL PHOSPHATE
Pulsatile drug delivery system is required to satisfy the needs of chronotherapy. Among solids, multiparticulates have its own advantages. Pulsatile drug delivery system provides better therapy with many of the actives....
EMERGENCE OF NATURAL SUPER-DISINTEGRNATS IN ORO-DISPERSIBLE TABLETS: AN OVERVIEW
Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrates or diss...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF AERVA LANATA ALONG WITH PRELIMINARY PHYTOCHEMICAL SCREENING
The aim of the present study was to investigate the antibacterial properties and phytochemical evaluation of of Aerva lanata. The organic solvent ( Ethanol, Methanol, Hexane) and water extracts from the whole plant of A...
TECHNOLOGY TRANSFER IN PHARMACEUTICALS
The Purpose of this review article is to discuss various critical paths for success of technology transfer. This article highlights the goal, methods, importance, facets and various models associated with technology tran...