SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND NIACIN IN TABLET DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Two UV spectrophotometric methods were developed and validated for quantitative determination of atorvastatin (ATR) and niacin (NIA) in tablet dosage form. Method I is based on the simultaneous equation, and method II is based on the absorbance ratio method. The absorption maxima were found to be at 246 nm and 262 nm in methanol for the atorvastatin and niacin respectively. Beer's law is obeyed in the concentration range of 5-25 µg/ml with correlation coefficient within range of 0.996 - 0.999 for both the drugs. The accuracy of the methods was assessed by recovery studies and found to be 99.77 ± 0.34 and 99.97 ± 0.17 by the simultaneous equation method, where as 99.78 ± 0.49 and 99.98 ± 0.39 by the absorbance ratio method for atorvastatin and niacin respectively.
Authors and Affiliations
Ramesh Sawant , Raihan Ahmed , Supriya Ramdin , Sheetal Darade
Keywords
Related Articles
- EP ID EP108771
- DOI -
- Views 128
- Downloads 0
IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES EVALUATION OF METHANOLIC EXTRACT OF CAESALPINIA PULCHERRIMA FLOWERS
The current study was conducted to prove ethno medicinal value of the plant, investigating anti-microbial, antioxidant, and total phenolic content of crude methanolic extract of flowers of Caesalpinia pulcherrima. The me...
A COMPARATIVE STUDY ON ONTOGENIC EXPRESSION OF ANTIOXIDANTS AND SECONDARY METABOLITES IN WITHANIA SOMNIFERA
Withania somnifera (WS), also known as Ashwagandha, Indian ginseng and winter cherry, has been an important herb in the ayruvedic and indigenous medical system for over 3000 years. Antioxidant activity and phytochemical...
STUDY ON THE EFFICACY OF IODINE BASED CONTRAST MEDIA FOR INTERPRETATION OF ROOT CANAL ANATOMY
Root canal anatomy in the human dentition is very complex. The radiographic identification of these root canal features may assist in the assessment and treatment of potential endodontic failures. The technique described...
SYNTHESIS, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF 5-[4-(SUBSTITUTED) BENZYLIDENE OR BENZYL] THIAZOLIDINE-2, 4-DIONE WITH THEIR ORAL HYPOGLYCEMIC ACTIVITY
A new series of 5-[4-(substituted) benzylidene or benzyl] thiazolidine-2, 4-dione (TZDs) have been synthesized using economical synthetic routes. The aim of the synthesis based on modification of linker region and effect...
OPTIMIZING ORAL DRUG DELIVERY USING LIPID BASED FORMULATIONS
A great challenge facing the pharmaceutical scientists is transforming the new pharmacologically active lipophilic compounds that are poorly water soluble into orally administered medications with sufficient bioavailabil...