Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate - Bromide Mixture
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2018, Vol 2, Issue 5
Abstract
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Teneligliptin in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate "“ Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed ?max at 250 nm. The linearity range for Teneligliptin is found to be 10 µgml to 250 µgml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 1.1645×104 lit molecm and 0.0366 µg mlcm2 respectively. I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq"Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate "“ Bromide Mixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018, URL: http://www.ijtsrd.com/papers/ijtsrd18253.pdf http://www.ijtsrd.com/physics/other/18253/spectrophotometric-oxidation-method-for-the-determination-of-teneligliptin-by-using-bromate---bromide-mixture/i-lakshmi-prasanna
Authors and Affiliations
Keywords
Related Articles
- EP ID EP390011
- DOI -
- Views 47
- Downloads 0
A Comprehensive Review on Clinical Pharmacology of Non Steroidal Anti Inflammatory Drugs
An increasing number of non steroidal anti inflammatory drugs NSAIDs is available for clinical use each year. This article reviews significant differences between NSAIDs currently available in worldwide, and helps the cl...
Design and Fabrication of Wheel Chair using Rocker Bogie Mechanism
Rocker bogie finds a vital role in determining the scientific analysis of objectives separated by many distance apart. The mobility design at present is quite a bit complex with many legs or wheels. The wheeled rover whi...
Damage Assessment System for Aircraft Structural Defects using Wavelet Transform
Defects are often arises on the inner surface of aircraft structures, but most of conventional techniques can determine only the damages and cannot determine the degree of damage. Digital Image Processing and Wavelet Tra...
The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes An In Silico Study
Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar leve...
Nurses Grief as a Reaction to Patient Death in Pediatric Units of BPKIHS
Introduction: Grief is a phenomenon that every human being eventually experiences. As healthcare providers who are in close contact with dying patients, nurses are vulnerable to experience grief. However the emotional as...