SPHERICAL AGGLOMERATION – DIRECT TABLETTING TECHNIQUE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 11
Abstract
Direct tabletting technique is the modern and the most efficient process used in tablet manufacturing and has been successfully employed for various poorly soluble and poorly compressible drugs. Spherical agglomeration is particle engineering technique which involves the transformation of fine crystals into spherical shape particles which enhances the powder properties such as particle size, shape, flow properties, solubility and bioavailability of pharmaceutical drug substances. This technique can also be applied to sustain the drug release from solid dosage forms. The present article is on the detailed comprehensive review about advantages and disadvantages, mechanism, different manufacturing methods of spherical agglomerates and characterization of spherical agglomerates.
Authors and Affiliations
Pradnya Patil , V. R. M. Gupta , R. H. Udupi , Srikanth K. , Nikunja Pati , Sree Giri Prasad
Keywords
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