Spherical Crystallization: A Novel Particle Design Technique
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 4
Abstract
Oral route is the most important route of drug administration. In this route, the solid dosage form specially tablets, are the first choice of patient but due to unfavorable physical and mechanical properties their formulation process becomes problematic. Crystallization is the main process in the pharmaceutical industry for particle formation, Where Spherical crystallization is a novel particle engineering technique developed. Basically, it's single step process used for size enlargement of drug. By which crystallization and agglomeration can be carried out simultaneously in one step and which has been successfully utilized for improvement of flowability, compactability and bioavailability of crystalline drugs. General methods of spherical crystallization are spherical agglomeration, emulsion, solvent diffusion method, ammonia diffusion method, neutralization method. Spherical crystallization is having wide applications in pharmaceuticals like improvement of flowability and compressibility of poorly compressible drugs, masking bitter taste of drugs and improving the solubility and dissolution rate of poorly soluble drug. Characterization of spherical crystals can be carried out using Optical Microscopy, Scanning Electron Microscopy, X-ray Powder Diffraction, Fourier Transform Infrared spectroscopy and Differential Scanning Calorimetry.
Authors and Affiliations
Bhagyashree Patil*, Ashish Jain, Aishwarya Mane, Bhawna Sharma
Keywords
Related Articles
- EP ID EP3734
- DOI -
- Views 364
- Downloads 21
EVALUATION OF SOME BRANDS OF SHAMPOOS ACCORDING TO THE LIBYAN STANDARD SPECIFICATION
There are many brands of shampoos in Tripoli markets-Libya, available from different sources, locally and imported from other different countries. The aim of this work was to investigate whether such brands comply with...
EVALUATION OF MECHANICAL PLAQUE REMOVAL EFFECTIVENESS OFTOOTHBRUSH AND ITS MODIFICATIONS IN INTELLECTUALLY DISABLEDCHILDREN.
Background: Disability is an umbrella term that includes aproblem in the body single-valued function or structure. Disabled children reveal a high prevalence of gingivitis and also show non-compliance towards brushing. H...
ACID BASE INDICATOR PROPERTY OF LAWSONIA INERIMES LEAVES
Indicators used in titration show well-marked changes of color in certain intervals of pH. Most of these indicators are organic dyes and are of synthetic origin. The environmental pollution caused by chemical industries...
Effect of Orange (Citrus sinensis) Peel Oil on Lipid Peroxidation, Catalase activity and Hepatic Biomarker levels in Blood Plasma of Normo Rats
Dietary antioxidants are considered beneficial because of their potential protective role against oxidative stress, which is involved in the pathogenesis of multiple diseases such as cancer and coronary heart disease....
CHRONOTHERAPY OF NOCTURNAL ASTHMA AND RECENT PATENTS: A REVIEW
The study of biological rhythms is called chronobiology. Many diseases have been found to show rhythm in their symptoms and severity. To treat such diseases the timing of drug administration is matched with circadian rhy...