Spinal Anaesthesia for Lower Abdominal Surgery: Levobupivacaine versus Racemic Bupivacaine
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Levobupivacaine is the pure S (-) enantiomer part of racemic mixture of bupivacaine. It is said to have local anaesthetic properties similar to racemic bupivacaine but with less cardiac toxicity. Aim: The aim of this study was to compare the efficacy and safety of these two local anaesthetic agents in patients undergoing lower abdominal surgery under spinal anaesthesia. Materials and Methods: One hundred and four American Society of Anaesthesiologists Physical Status Grade I-II patients undergoing inguinal hernioplasty or hydrocele excision were randomized to receive an intrathecal injection of one of two types of local anaesthetic solutions. Group L patients (n=52) received 3 mL (15 mg) of isobaric levobupivacaine while Group B patients (n=52) received 3 mL (15 mg) of isobaric bupivacaine. Onset of sensory block at L1, peak sensory level attained and time taken for it, two segment regression time from highest sensory level, time for regression back up to L1 level, onset and intensity of motor block, time to attain maximum motor block and its duration were recorded. Vital parameters and adverse effects in relation to spinal anaesthesia were also observed. Quantitative data were presented as mean and standard deviation (mean±Sd) and intergroup data were analysed by unpaired t-test. Results: The two groups were comparable to each other with respect to sensory block characteristics (p>0.05). Time to attain maximum Bromage grade was significantly faster in Group B (8.03±1.91) compared to group L (10.06±1.38); (p<0.0001). There was no statistically significant difference in other motor block characteristics, vital parameters and perioperative complications between the two groups (p>0.05). Conclusion: Thus, isobaric levobupivacaine (0.5%) appears to be a good alternative to isobaric bupivacaine (0.5%) in spinal anaesthesia for inguinal hernioplasty and hydrocele excision.
Authors and Affiliations
Roma Tejaskumar Kalaria, Mahendra Ramkrishna Upadhyay
Keywords
Related Articles
- EP ID EP521059
- DOI 10.7860/JCDR/2018/31422.11327
- Views 45
- Downloads 0
Is the Cage an Additional Hardware in Lumbar Interbody Fusion for Low Grade Spondylolisthesis? A Prospective Study
Introduction: Lumbar interbody fusion has become the standard of care for the management of lumbar instability, where fusion is achieved using bone grafts, cages, etc. Aim: The aim of the study was to compare the outcome...
Molecular Imprints of Bacteria in Oxalate Containing Kidney Stone: A Preliminary Report
ABSTRACT Introduction: Most of the world’s part, including India comes under stone belt area, where incidences and frequency of kidney stone are high. Presence and diversity of bacteria inside the Calcium-Oxalate (CaOx)...
A Case Report of Largest Documented Multilocular Cystic Nephroma Removed by Thoracoabdominal Approach
Large renal tumours are not uncommon in developing countries. Enhancing renal tumours are considered to be malignant unless proved otherwise and radical surgical resection remains the mainstay of treatment of such tumour...
Burn Wound Healing Potential of Honey, Sandal Wood, Calendula and Cooling with Tap Water-A Comparative Study on Wistar Rats
ABSTRACT Introduction: Burn injury is always associated with high morbidity and mortality depending on the percentage of burns. Slow wound healing, infection, pain, and hypertrophic scarring continue to remain a major c...
Validity of Current Treatment Protocols to Overcome Hypochondriasis
ABSTRACT Hypochondriasis has been difficult to define and its classification amongst diseases has been blurred since, time immemorial. Though decades have been passed since its discovery and known to the people that the...