Spinal muscular atrophy counteracted by Agrin biological NT-1654
Journal Title: Journal of Neuroscience and Neurological Disorders - Year 2018, Vol 2, Issue 1
Abstract
Spinal muscular atrophy (SMA) is a genetic and gravely disease, portrayed by motor neuron (MN) death, thereby leading to progressive and accelerating muscle fragility, respiratory collapse, and, in the most severe cases, it even pave the way to death. At the neuromuscular junction (NMJ), abnormally have been reported in SMA, including neurofilament (NF) aggregation at presynaptic terminals, immature and smaller endplates, lowered transmitter release, and, eventually, muscle denervation. In this review the role of Agrin in SMA is studied. This review highlights the antagonizing role of Agrin in SMA.
Authors and Affiliations
J Paul
Keywords
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- EP ID EP555108
- DOI 10.29328/journal.jnnd.1001009
- Views 73
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