Spink1 Mutation in Idiopathic Recurrent Acute Pancreatitis- A Pilot Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP) are labeled as idiopathic when no identifiable factors are found. The identification of genetic mutations associated with pancreatitis have provided opportunities for identifying patients at risk for idiopathic pancreatitis. Aim: The aim of the present study was to study the clinical profile and prevalence of SPINK1 mutation in idiopathic RAP. Materials and Methods: The present study was a prospective observational study of idiopathic RAP patients at a tertiary care hospital. DNA was isolated from blood obtained from patients and genotyping of SPINK1 mutation was studied. Results: A total of 17 patients with idiopathic RAP were included. Their mean age was 22.29±9.7 years, 14 (82%) were male, 7 (41.7%) had SPINK1 mutation. Patients with SPINK1 mutations had more frequent acute episodes of pancreatitis. Conclusion: SPINK1 mutation patients have more frequent acute episodes of pancreatitis and nearly 7 (41.7%) had SPINK1 mutations in the so called idiopathic RAP. Genetic testing in idiopathic pancreatitis might have role in future. Multicenter studies are further required to confirm the role of genetic testing in RAP.
Authors and Affiliations
Shiran Shetty, Thaiagarajan Sairam, Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Ramalingam Sankaran
Keywords
Related Articles
- EP ID EP510127
- DOI 10.7860/JCDR/2018/32370.11342
- Views 60
- Downloads 0
A Review of Clinical Evaluation and Management of Delirium
ABSTRACT Delirium is a syndrome characterised by the acute onset, fluctuating course of disturbed consciousness and cognitive impairment. It is an important medical condition with poor outcomes. Delirium is still under-r...
Influence of Different Thickness of Mineral Trioxide Aggregate, Resin Modified Glass Ionomer Cement and Intermediate Restorative Material on Sealing Ability of Root End Fillings: An in vitro Study
Introduction: A wide variety of root end filling materials has been tried, though the biocompatibility and sealing ability have been always in question. Hence, the latest innovation towards better sealing materials like...
Pathological and Biochemical Evaluation of Toxic Effects of Repeated Administration of Jasada Bhasma (Zinc Ash Formulation) in Wistar Albino Rats
Introduction: Jasada Bhasma is the well known potent zinc formulation commonly used in ‘Ayurveda’ medicine system. Its extensive usage in the health care sector is proved to be successful in the treatment of certain illn...
Angulated Custom Cast Post and Core Restoration for Traumatised Anterior Tooth-“Not as Straight as an Arrow”
ABSTRACT Traumatic dental injuries are most common injuries afflicting young children and generally involve the maxillary anterior teeth. Increased overjet with protrusion of upper incisors and insufficient lip closure a...
Emergency Caesarean Section in a Patient with Undiagnosed Eisenmenger’s Syndrome with Severe Pulmonary Hypertension
ABSTRACT Pregnancy is associated with major physiologic changes in various organ systems of the body, especially the cardiovascular system. This is especially dangerous in the presence of pre-existing Pulmonary Artery Hy...