Sporadic Parkinsonism-Dementia Complex of Rhode Island with Unusually Abundant Glial TDP-43 Immunoreactivity
Journal Title: Journal of Parkinson’s Disease and Alzheimer’s Disease - Year 2017, Vol 4, Issue 2
Abstract
Background: Parkinson’s disease can overlap with other forms of neurodegeneration; however its co-occurrence with both frontotemporal lobar degeneration and motor neuron disease is distinctly rare although characteristic of Parkinsonism-Dementia Complex of Guam (PDCG). Materials and methods: Herein we report a case of a 69-year-old man from Rhode Island whose insidious developments of Parkinson’s and motor neuron diseases were followed by a rapidly progressive cognitive decline. Results: The postmortem neuropathological findings were highly reminiscent of PDCG but accompanied by an unusual abundance of TDP-43 immunoreactivity in glia rather than neurons. Conclusion: This case highlights the potential contributions of glial cell dysfunction and TDP-43 pathology in the pathogenesis of neurodegeneration.
Authors and Affiliations
Suzanne M. de la Monte
Keywords
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- EP ID EP496808
- DOI 10.13188/2376-922X.1000024
- Views 153
- Downloads 0
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