Stability and Stabilization of Pabialgin (Cibalgin) Liquid Preparation
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2021, Vol 5, Issue 3
Abstract
Shelf-life time was supposed to be determined for active principles of original Pabialgin® (Cibalgin®) drops (allobarbital, aminophenazone) and for its stabilized liquid formulation using accelerated testing at elevated temperatures. The paper chromatography-spectrophotometric selective method was used for the determination of allobarbital and aminophenazone in presence of themselves as well as solubilisates and antioxidants. The semi-logarithmic Arrhenius equation was used to calculate shelf-life times at ambient temperature, from apparent first-order rate constants, determined at elevated temperatures. Since shelf-life times of allobarbital and aminophenazone in original pabialgin® liquid formulation were not satisfactory certain stabilization attempts were undertaken. First of all, water as a solvent was replaced with glycerol to inhibit a hydrolytic pathway of allobarbital degradation, and some antioxidants were introduced to stabilize photo-oxidation processes involved in the degradation of aminophenazone. It resulted in an unusual increase in shelf-life times of the abovementioned active principles. Aminophenazone is now replaced with propyphenazone in the so-called neo pabialgin P, because it can be transformed into a potentially cancerous nitrosamine. However, propyphenazone is also a derivative of 1-phenyl2,3-dimethylpyrazolone-5 similar to aminophenazone. Therefore, it should be also susceptible to oxidative processes and our findings could be used within the framework of pharmaceutical work to stabilize pabialgin P as well. A new stabilization technology of pabialgin has been successfully patented.
Authors and Affiliations
Hermann J1 and Hermann TW2*
Keywords
Related Articles
- EP ID EP748586
- DOI 10.23880/oajpr-16000250
- Views 72
- Downloads 0
Preparation and Characterization of Sodium Alginate- Eudragit E100 Based Systems with Prospective Pharmaceutical Delivery to Application
Regarding the preparation of a local drug delivery system, the possibility of incorporating an active substance in a matrix system was investigated to prolong the drug release. A complex between sodium alginate and a tr...
Density Functional Study of Aflatoxin B1, B2, G1 and G2: NBO and AIM Analyses
Aflatoxin, belonging to the bisfuranocoumarine group of organic compounds, encompasses several species such as aflatoxin B1, B2, G1, and G2. In this study, geometry optimizations of these aflatoxins were conducted using...
Nanotechnology Integration in Education: Challenges, Strategies and Prospects
Nanotechnology is a rapidly evolving interdisciplinary field with vast potential applications across various sectors, including medicine, electronics, and energy. Its integration into education presents both opportuniti...
Study on the Prevalence of Hyperuricemia and Ethnobotanicals Associated with Gouty Arthritis in Rawalakot, Azad Kashmir
Hyperuricemia prevalence is an exclusive condition in the global populace as it seems to have increased day by day for a long time now. Recent studies recommend that hyperuricemia is an issue and is considered an indepe...
Quantum Dots: Need to Explore Potential for Delivery of Drugs and Biomolecules
Quantum dots (QDs) are the semiconductor nanoparticles having the range of 2 nm to 10 nm [1]. One of the properties of semiconductor metals of the group IV to group VI of periodic table, to show fluorescence is establish...