STABILITY ASSESSMENT OF BISOPROLOL FUMARATE UNDER DIFFERENT STRESS CONDITIONS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 9
Abstract
Objective: To assess the stability of Bisoprolol Fumarate under different stress conditions. Methods: Different samples of Bisoprolol Fumarate standard were subjected to a variety of stress conditions as a temperature, a combination of temperature and relative humidity, direct sunlight, acid/base hydrolysis, and oxidation were subsequently analysed. The analysis was carried out using RPHPLC system equipped with UV/vis detector. Results: Bisoprolol Fumarate was stable in diluent when exposed for 72 hrs (at room temperature). The results of analysis showed that the drug standard was 99.50% which proves that no degradation. When the drug was subjected to 75ºC for 6 hours (Dry Temperature), there was no change in drug potency. No change in the assay content when Bisoprolol Fumarate was exposed to a temperature of 105ºC for one hour. Upon exposure to sunlight in a temperature recorded between (35-40ºC) for 72 hours, Bisoprolol Fumarate was unstable, the drug content decreased to 95.73%. The effect of heat and relative humidity was a decreased in drug assay (i.e. from 99.69% to 93.78%) for one month. Bisoprolol Fumarate was affected by acid and base hydrolysis (0.1M), the drug content was decreased from 99.96% to 94.72% and 91.60% respectively. Moreover, the drug was affected by oxidation (30% H2O2) and the drug content decreased from 99. 96 % to 96.91%. Conclusion: Bisoprolol Fumarate stability was effected when exposed to different stress conditions.
Authors and Affiliations
Dr. Abdullah Ali Yahya AL-Asali
Keywords
Related Articles
- EP ID EP630792
- DOI -
- Views 169
- Downloads 0
OVARIAN CYSTIC LYMPHANGIOMAS: A CASE REPORT
Lymphangioma is a rare benign neoplasm of the lymphatic system comprised of multiple cystic spaces lined with endothelium. It may arise in any part of the body. Ovarian localisation is exceptional and only few cases have...
TREATMENT PROTOCOLS FOR THE MANAGEMENT OF MIGRAINE
Migraine is an episodic headache which affects almost more than 10% of population and three times more frequently in women than men. One of the main problems in the success of new therapeutic approaches is our limited kn...
A CASE STUDY AND CLINICAL LITERATURE REVIEW OF FOURNIER’S GANGRENE, DEMONSTRATING RESOLUTION WITH ANTIBIOTIC THERAPY AND IN THE ABSENCE OF SURGICAL OR ANY OTHER INTERVENTION
This case report describes a lesser common condition, namely Fournier's gangrene, involving a rapidly advancing, necrotising infection of deep tissues, starting from the perineal area with spread along fascial planes. Th...
INFLUENCE OF STORAGE CONDITIONS ON PHARMACEUTICAL PROPERTIES OF SOME MARKETED BRANDS OF PARACETAMOL TABLETS AVAILABLE IN TRIPOLI AREA
This work was conducted after reporting a 2 months of poor storage conditions of temperature and humidity in some pharmacies during power outage on summer 2014 which led us to evaluate and compare the influence of differ...
ROLE OF CYTOKINES(INF- Γ, IL-6, IL-10) IN THE PATHOGENESIS OF AUTOIMMUNE TYPE I DIABETES MELLITUS
Type I diabetes mellitus is an autoimmune disease; it is one of most serious and common metabolic disorders in children and adolescents, in which the body immune system destroys the insulin releasing beta cells. Thus, th...