Stability Indicating HPLC Method Development A Review
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2021, Vol 5, Issue 5
Abstract
High performance liquid chromatography HPLC is an essential analytical tool for evaluating drug stability. HPLC methods must be able to isolate, detect, and quantify drug related degradation products that may form during storage or production, and identify drug related impurities that may form during synthesis. .. This article describes strategies and challenges for designing HPLC methods to demonstrate drug stability. It will deepen our understanding of drugs and medicinal chemistry and demonstrate advances in stability that reflect an analytical approach. Several important chromatographic parameters were investigated to improve the detection of potentially related degradants. It is necessary to find suitable solvent and mobile phase samples that provide sufficient stability and compatibility with each component and potential impurities and degradants. This method should be carefully considered as it has the ability to distinguish between primary and secondary decomposers. The study of forced destruction of chemicals and new drugs is essential for the development and characterization of these immobilization methods. Practical guidance is provided at each stage of drug development to develop a forced disposal protocol and avoid common issues that might impede data interpretation. Suraj Nagwanshi | Smita Aher | Rishikesh Bachhav "Stability Indicating HPLC Method Development - A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46310.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/46310/stability-indicating-hplc-method-development--a-review/suraj-nagwanshi
Authors and Affiliations
Suraj Nagwanshi | Smita Aher | Rishikesh Bachhav
Keywords
Related Articles
- EP ID EP700018
- DOI -
- Views 87
- Downloads 0
Application of Nonlinear Two-Dimension Wave Equation Dual Reciprocity Boundary Element Method
The constructive numerical implementation of the two-dimensional dual boundary element method. This paper present to solve nonlinear 2-D wave equation defined over a rectangular spatial domain the boundary conditions. Tw...
Impact of Outsourced Housekeeping Services on Guest Satisfaction with Respect to Star Hotels
The main goal of Hotel industry business is to meet guests needs while achieving profit targets. The Guest satisfaction is the very important factor for the Hotel industry. It enhances Hotels reputation, increases room s...
Over Review on Plant Tissue Culture
Plant tissue culture has been widely employed in area of agriculture, horticulture, forestry and plant breeding. It is an applied biotechnology used for mass propagation, virus elimination, secondary metabolite productio...
African Traditional Medicine A Primer
African traditional medicine is a holistic health practice that uses indigenous herbalism combined with some aspects of spirituality. It involves the direct application of herbal remedies, animal parts, or mineral materi...
Agricultural Waste Materials as Potential Adsorbent for Treating Industrial Waste Water
Nowadays, the people suffer a lot due to water pollution and it becomes a serious problem. Therefore, it is very important to minimize the water pollution and utilize the treated waste water for domestic purpose. The pri...