Stability Indicating HPLC Method Development A Review
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2021, Vol 5, Issue 5
Abstract
High performance liquid chromatography HPLC is an essential analytical tool for evaluating drug stability. HPLC methods must be able to isolate, detect, and quantify drug related degradation products that may form during storage or production, and identify drug related impurities that may form during synthesis. .. This article describes strategies and challenges for designing HPLC methods to demonstrate drug stability. It will deepen our understanding of drugs and medicinal chemistry and demonstrate advances in stability that reflect an analytical approach. Several important chromatographic parameters were investigated to improve the detection of potentially related degradants. It is necessary to find suitable solvent and mobile phase samples that provide sufficient stability and compatibility with each component and potential impurities and degradants. This method should be carefully considered as it has the ability to distinguish between primary and secondary decomposers. The study of forced destruction of chemicals and new drugs is essential for the development and characterization of these immobilization methods. Practical guidance is provided at each stage of drug development to develop a forced disposal protocol and avoid common issues that might impede data interpretation. Suraj Nagwanshi | Smita Aher | Rishikesh Bachhav "Stability Indicating HPLC Method Development - A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46310.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/46310/stability-indicating-hplc-method-development--a-review/suraj-nagwanshi
Authors and Affiliations
Suraj Nagwanshi | Smita Aher | Rishikesh Bachhav
Keywords
Related Articles
- EP ID EP700018
- DOI -
- Views 91
- Downloads 0
Role of Correlation in Business and Day to Day Life
The researcher has done the research on the topic Role of Correlation in Business and Daily life. Correlation studies the relationship between two variables in which change in the value of one variable, are associated wi...
Women Entrepreneurship in India
Women Entrepreneurs may be defined as the women or a group of women who initiate, organize and operate a business enterprise. Government of India has defined women entrepreneurs as an enterprise owned and controlled by a...
Manoj Das An Incredible Bridge between Literature and Philosophy
Attempts have been taken here to unveil the versatile virtuosity and artistry of Manoj Das especially in his literary attempts which walk with an incredible alliance with philosophy underneath the literary vesture. Apart...
Alternative RAM Mapping Algorithm for Embedded Memory Blocks in FPGA
Contemporary ?eld-programmable gate array (FPGA) design requires a spectrum of available physical resources. As FPGA logic capacity has grown, locally accessed FPGA embedded memory blocks have increased in importance. Wh...
Accident Alert System using Advance Microcontroller
In India most of the accidents are happening due to vehicles over speeding. Sometimes if obstacle is close to the vehicle then they won't be able to judge the distance to apply instant brakes and accident is occurred. To...