Stability Indicating Spectrophotometric Methods Determination of Nicardipine in the Presence of its Alkaline Induced Degradation Products
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: Derivative, ratio spectra derivative and ratio difference spectrophotometric methods were developed and validated for simultaneous determination of Nicardipine (NIC) in the presence of its alkaline induced degradation products. Methods: In these methods the overlapped spectra of NIC and its alkaline induced degradation products were well resolved by measuring the amplitudes of first derivative (D1) spectra and the second derivative (D2) at 382.3 and 239 nm, respectively. NIC was determined by ratio spectra derivative by measuring the amplitude at 244 nm. The ratio difference spectrophotometric method was developed in which the difference between amplitudes at 237.5 nm and 260 nm of the ratio spectra were recorded. The linearity range for the applied methods was 2-18 μg/ml.Results: All the developed methods were validated according to ICH Guidelines, NIC was determined with acceptable accuracy and precision.Conclusion: These methods were suitable as stability indicating methods for the determination of NIC in the presence of its alkaline induced degradation products either in bulk powder or in a pharmaceutical formulation. Statistical analysis of the results with those obtained by applying a reported method has been carried out revealing high accuracy and good precision.Keywords: Nicardipine, Spectrophotometry, Pharmaceutical preparations, Stability indicating, derivative, ratio derivative and ratio difference
Authors and Affiliations
Hayam Mahmoud Lotfy, Maha Abd El-monem Hegazy, Mai M. Abd El-aziz, Laila Elsayed Abdel Fattah
Keywords
Related Articles
- EP ID EP577769
- DOI -
- Views 37
- Downloads 0
PREPARATION AND CHARACTERIZATION OF CURCUMIN LOADED CASSAVA STARCH NANOPARTICLES WITH IMPROVED CELLULAR ABSORPTION
Objectives: The present study describes loading of curcumin onto cassava starch nanoparticles to improve its cellular absorption.Methods: Cassava starch nanoparticles were prepared by acid hydrolysis. A solution of curcu...
ENHANCED PRODUCTION OF PSORALEN THROUGH ELICITORS TREATMENT IN ADVENTITIOUS ROOT CULTURE OF PSORALEA CORYLIFOLIA L.
Objective: The present study aimed to determine the effect of two elicitors namely Methyl Jasmonate (MeJ) and Salicylic acid (SA) on adventitious root production of Psoralea corylifolia L. as the elicitors and at differe...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC DETERMINATION OF CEFPODOXIME PROXETIL IN PURE AND TABLET DOSAGE FORMS THROUGH ION-PAIR COMPLEX FORMATION USING BROMOTHYMOL BLUE
Objective: A simple, direct and accurate spectrophotometric method has been developed for the determination of cefpodoxime proxetil (CEFP) in pure and pharmaceutical formulations by complex formation with bromothymol blu...
INDIRECT SPECTROPHOTOMETRIC ESTIMATION OF DRUGS USING CERIUM (IV) AND RHODAMINE-B AS ANALYTICAL REAGENT
Objective: The object of this research was to develop simple, sensitive and selective methods for the quantitative determination of five drugs, viz., (RAM) Ramipril, (VOR) Voriconazole, (SDC) Sildenafil Citrate, (ITM) Im...
EFFECTIVENESS OF TICAGRELOR COMPARED TO CLOPIDOGREL IN REDUCING THE RISK OF MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY HEART DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTION
Objective: Antiplatelet therapy is recommended in patients with coronary heart disease (CHD) who had the percutaneous coronary intervention (PCI) procedure to reduce major adverse cardiovascular events (MACE). There has...