Stability Study of Artesunate under Stress Condition Using High Performance Liquid Chromatography Method
Journal Title: Asian Journal of Chemical Sciences - Year 2017, Vol 2, Issue 1
Abstract
The stability of Artesunate in solid state and Liquid towards direct sunlight showed first-order reaction kinetic rate, the reaction rate of artesunate was pH dependent. The rate of photothermal decomposition in aqueous medium was found to speed up the reaction while the pH decreased. The hydrolysis of artesunate in the alkaline medium was very low compared to acid medium hydrolysis. All the investigated pharmaceutical excipients were found to accelerated the thermal instability of artesunate at 70°C in an aqueous medium. The tendency of which to accelerated the thermal stability was in the following order: povidone, aerosil, propyl paraben, methyl paraben, sodium benzoate, maze starch and talcum powder. Artesunate was affected when exposed to UV radiation in solid and liquid form, artesunate is a photolabile drug. The results obtained from the accelerating stability study of artesunate for four months showed that no change in chemical and physical properties of artesunate. Official HPLC method was used it’s not enough to determinate decomposed products of artesunate degradants.
Authors and Affiliations
Elsadig H. R. Rajab, Ahmed E. M. Saeed
Keywords
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- EP ID EP338856
- DOI 10.9734/AJOCS/2017/31274
- Views 130
- Downloads 0
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