Stability Study of Artesunate under Stress Condition Using High Performance Liquid Chromatography Method
Journal Title: Asian Journal of Chemical Sciences - Year 2017, Vol 2, Issue 1
Abstract
The stability of Artesunate in solid state and Liquid towards direct sunlight showed first-order reaction kinetic rate, the reaction rate of artesunate was pH dependent. The rate of photothermal decomposition in aqueous medium was found to speed up the reaction while the pH decreased. The hydrolysis of artesunate in the alkaline medium was very low compared to acid medium hydrolysis. All the investigated pharmaceutical excipients were found to accelerated the thermal instability of artesunate at 70°C in an aqueous medium. The tendency of which to accelerated the thermal stability was in the following order: povidone, aerosil, propyl paraben, methyl paraben, sodium benzoate, maze starch and talcum powder. Artesunate was affected when exposed to UV radiation in solid and liquid form, artesunate is a photolabile drug. The results obtained from the accelerating stability study of artesunate for four months showed that no change in chemical and physical properties of artesunate. Official HPLC method was used it’s not enough to determinate decomposed products of artesunate degradants.
Authors and Affiliations
Elsadig H. R. Rajab, Ahmed E. M. Saeed
Keywords
Related Articles
- EP ID EP338856
- DOI 10.9734/AJOCS/2017/31274
- Views 117
- Downloads 0
New Synthetic Pathways for Thiocarbohydrazide and Salicylaldehyde Azine Compounds
Thiocarbohydrazide synthesis is an important intermediate step for many hydrazine organic synthetic reactions. Synthesis of thiocarbohydrazide can be done by reaction of carbon disulfide with hydrazine (hydrazinolysis) i...
Free Radical Scavenging Activity of Jatropha curcas Leaves, Phytochemical and Antibacterial Analysis of Its Butanol Crude Extract
The use of different plant parts for the prevention and cure of ailments, infections and diseases as an alternative to the use of orthodox medicine is gaining more attention. Moreso, resistance to orthodox drugs has been...
Effect of Thiourea Concentration on Structural, Optical and Electrical Properties of Cu2ZnSnS4 Thin Films Prepared by using Spray Pyrolysis
Thin films of Cu2ZnSnS4 (CZTS) with different molar concentrations of thiourea were prepared on glass substrates using spray pyrolysis technique. The structural, optical and electrical properties of the CZTS thin films w...
The Numerical Study of Effects of Soret, Dufour and Viscous Dissipation Parameters on Steady MHD Casson Fluid Flow through non-Darcy Porous Media
In the present paper the numerical study of effects of Soret, Dufour and viscous dissipation parameters on steady MHD Casson fluid flow through non-Darcy porous medium is explored. By suitable similarity transformations,...
Organochlorine Pesticide Residue Levels and Potential Human Health Risks in Kolanuts from Selected Markets in Osun State, Southwestern Nigeria
Organochlorine Pesticide (OCP) residue were qualitatively and quantitatively determined using Gas Chromatography-Electron Capture Detector (GC-ECD) and their potential health risks assessed in kolanut (Cola nitida) sampl...