Standardization of Vyoshadi Saktu a Pathykalpana (Nutritional supplement) in Diabetes

Journal Title: The Journal of Phytopharmacology - Year 2016, Vol 5, Issue 6

Abstract

Neuropathy and Cardiac complications are the most common trouble in diabetes mellitus with progressive damage due to complex pathogenesis. Many conventional pharmacological agents were withdrawn from clinical studies either due to lack of efficacy or due to side effects on major organs. Over the period of time traditional herbal plants were utilized in the treatment & management of diabetic complications. The aim of the present research work was to investigate efficacy and dynamics of Operculina turpethum root (OT) in STZ induced diabetic neuropathy and cardiac complications. Chronic treatment of crude extract of OT (500 mg/kg) showed positive effect in diabetic animals with significant reduction in blood glucose level, serum nitrite, brain homogenate nitrite & nerve homogenate nitrite levels as compared to diabetic control animals. Treatment with OT showed significant rise in body weight compared to Control animals & polyphagia were observed in diabetic animals persisted throughout the period of 8 weeks. Significant improvement was observed by treatment with OT in behavioural parameters like tail flick latency reduction and rise in pain threshold capacity. Nerve conduction velocity measured through BIOPAC system showed significant (P<0.05) improvement in diabetic animals, while improvement were observed in ECG profile, R-R interval, R wave amplitude, heart rate & cardiac hypertrophy index in diabetic animals when treated with OT. It was concluded from results that there is definite role of Operculina turpethum in the treatment and management of major diabetic complications.

Authors and Affiliations

Arati Dubewa, Medha Kulkarni, Anupama Dashetwar

Keywords

Related Articles

In vitro Anti-coagulant Activity of Dalbergia sissoo Bark

Dalbergia sissoo belonging to family Fabaceae is a widely growing plant and has been reported to possess multiple therapeutic properties like analgesic, anti-inflammatory, analgesic and antipyretic anti-ulcer, antioxid...

Understanding the role of quercetin during neurotoxicity induced by Chlorpyrifos

Organophosphate Chlorpyrifos (CPF), a pesticide, is widely used across the world to control worms and insects. It is highly toxic and causes neurobehavioral disorders. Naturally occurring compounds having polyphenols a...

Anti-diabetic effects of stem bark extract and fractions of Terminalia catappa Linn. (Combretaceae)

The pharmacognostic, toxicity and anti-diabetic profiles of stem bark of Terminalia catappa were evaluated. The plant material was subjected to macroscopy, microscopy and proximate analyses using standard methods. The...

Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats

Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containin...

GC-MS analysis and Antioxidant activity of essential oil of Artemisia amygdalina from Kashmir, India

The essential oil composition of the leaves of Artemisia amygdalina, growing in Kashmir, India, along with its antioxidant activity, is reported in the present study. Gas chromatography coupled with mass spectrometry (...

Download PDF file
  • EP ID EP49705
  • DOI -
  • Views 189
  • Downloads 0

How To Cite

Arati Dubewa, Medha Kulkarni, Anupama Dashetwar (2016). Standardization of Vyoshadi Saktu a Pathykalpana (Nutritional supplement) in Diabetes. The Journal of Phytopharmacology, 5(6), -. https://europub.co.uk/articles/-A-49705