STATISTIC ESTIMATION OF BREAKING TABLETS OF ENALAPRIL 20 MG
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 6
Abstract
Objective: The aim of this study was to evaluate the accuracy of breaking into half and quarter-tablets Enalapril 20 mg sold in the Albanian market, in dosages suitable for use in children.Methods: 100 whole tablets of Enalapril 20 mg were chosen at random from each of three different manufacturers based on scoring characteristic: scored on one side, scored on both sides and not scored. Whole tablets from each of the three product types were weighed and the mean weight calculated. The pills were then split in half and quarter by using a pill-splitter. The resulting half-tablets and quarter-tablets were weighed and the mean weights were calculated.Results: All the whole tablets were found to conform to the set criteria. Only halves from those tablets scored on both sides passed the weight uniformity test, with no individual half outside the 85-115 % range. Quarter-tablets failed the weight uniformity test. A higher relative standard deviation was observed for half and quarter-tablets of the not-scored tablet.Conclusion: The study shows that deviations in weight were observed in half tablets and quarter tablets of Enalapril 20 mg. These deviations were related to the presence or not of the score line. Such inadequate breaking of the tablets may result in dose variability and complicate therapeutic outcome.Keywords: Enalapril, Breaking tablets, Pediatric formulations, Score line
Authors and Affiliations
Briseida Dosti, Ledjan Malaj, Delina Xhafaj
Keywords
Related Articles
- EP ID EP576338
- DOI -
- Views 56
- Downloads 0
DEVELOPMENT AND EVALUATION OF IN SITU NASAL MUCOADHESIVE GEL OF METOPROLOL SUCCINATE BY USING 32 FULL FACTORIAL DESIGN
Objective: To develop and evaluate in situ nasal mucoadhesive gel of metoprolol succinate.Methods: In situ nasal mucoadhesive gel was formulated by cold method using Carbopol 940 as a pH sensitive polymer, xanthan gum as...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF CURCUMIN AND CYCLOSPORINE BY RP-HPLC
Objective: The present work was undertaken with an aim to develop and validate a rapid reverse-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of curcumin and cyclosporine in the capsule...
PHARMACIST INTERVENTION AND PREPARATION OF MANUAL IN THE ADMINISTRATION OF DRUGS THROUGH ENTERAL FEEDING TUBE
Objective: To monitor errors in current practice and prepare a manual for proper drug administration through the enteral feeding tube.Methods: It is a prospective observational study conducted for a period of 6 mo in eig...
DESIGN, SYNTHESIS AND BIOLOGICAL SCREENING OF AMINOACETYLENIC TETRAHYDROPHTHALIMIDE ANALOGUES AS NOVEL CYCLOOXYGENASE (COX) INHIBITORS
Objective: To design and synthesise a new amino acetylenic tetrahydro phthalimide derivative and investigate their selective inhibitory activity to COXs.Methods: Aminoacetylenic tetrahydro phthalimide derivatives were sy...
PHYTOCHEMIMCAL ANALYSIS OF WRIGHTIA TINCTORIA BARK EXTRACT IN WATER USING GC-MS
Objective: In the present study, phytochemical constituents of crude water extract of Wrightia tinctoria (WT) bark is done using GC-MS technique. Wrightia tinctoria is an important medicinal herb being used in tribal are...