STATUS OF PERMEABILITY OF BIOMEMBRANE IN WORKERS UNDER CONDITIONS OF DUST-MAKING PRODUCTION
Journal Title: Вісник Одеського національного університету. Біологія - Year 2017, Vol 22, Issue 2
Abstract
Introduction. The state of cell membranes is one of the most important factors in the regulation of homeostasis and the provision of biochemical and physiological processes in organism, the change in their structure and function is one of the main universal links in the development of disorders of bronchopulmonary system functioning. Purpose. The objective of the study was to identify the dependence of the shifts in the permeability of erythrocyte membranes on the duration of exposure to industrial quartz-containing dust and to determine its possible negative impact on the workers’ health. Methods. The study involved 249 foundry workers: 107 practically healthy people that were divided into groups according to their work experience under high dust concentration condition, 101 workers with obstructive and 41 with restrictive disturbances of lung ventilation. Permeability of erythrocyte membranes and peroxide hemolysis were assessed by the hemolysis curve of isotonic solutions of urea and sodium chloride. Results. It was found that in work experience groups of healthy workers the permeability index of erythrocyte membranes was reliably reduced compared to the control. The level of peroxide hemolysis signifiantly increased only in people with more than 20 - year long work experience in hazardous occupational environment. It may be indication of the processes aimed at preserving the morphological continuity of the cells, as well as the insuffiient effectiveness of compensatory mechanisms. The comparison of the indexes of healthy workers and workers with disorders of lung ventilation showed that the permeability of erythrocyte membranes significantly disturbed in the latter groups; moreover, notable violations were detected in people with obstructive breathing disorders. Conclusion. It was established that prolonged exposure to industrial dust affects permeability of erythrocyte membranes, suppresses compensatory mechanisms and signifiantly increases the risk of bronchopulmonary pathology.
Authors and Affiliations
N. O. Pylypenko, E. Y. Nikolenko, K. V. Vovk
Keywords
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- EP ID EP322827
- DOI 10.18524/2077-1746.2017.2(41).112253
- Views 69
- Downloads 0
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