Status of Some Hematological and Antioxidant Parameters in SCA Patients of Chhattishgarh Region
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
In India, haemoglobinopathies, especially sickle hemoglobin are the commonest genetic disorders in the tribal belt of Central and Southern India. Madhya Pradesh and Chhattisgarh harbours the largest tribal population in India, which is about one fourth of the total tribal population of the country. The prevalence of sickle haemoglobin from various parts of Madhya Pradesh and Chhattisgarh varied from 15 to 30 percent. The study was carried out in Chhattisgarh Institute of Medical Sciences, Bilaspur (C.G.). Since the Eastern region of central India is prone to Sickle Cell Anemia. Hence samples preferably collected from this area. The study was conducted on 120 human subjects. out of which 40 were suffering from Sickle cell disease , 40 were Sickle Cell Trait and 40 were taken as control group. Hematological parameter & antioxidants parameters were estimated. Hb, RBC, decreased significantly ( P<0.001) while HCT (P<0.05) in Group III and in Group II also decreased significantly (P<0.05) while there is no significant change were found in the level of MCV in both group as compare to control. The level of antioxidants significant (P<0.001) decrease except SOD in group II as compare to controls. In group III the level of antioxidant decreased significantly ( P<0.05) except SOD as compare to control. In subjects with homozygous sickle cell anemia, level of Plasma Malondialdehyde (MDA) were significantly (P<0.001) increased as compare to controls. Thus our study shows elevated plasma MDA and depleted antioxidant vitamins indicate oxidative stress in SCD. Therefore supplementation with antioxidants vitamin may ameliorate some of the sickle cell symptoms and improve quality of life
Authors and Affiliations
Vikas K. Gupta
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