STATUS OF VITAMIN-D DEFICIENCY IN SICKLE CELL DISEASE IN ADULTS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 45
Abstract
BACKGROUND Sickle cell disease is a prevalent and a widely distributed disease in India. It has been found to be associated with multiple complications such as vaso-occlusion and painful crisis. The aim of the study is to assess the status of vitamin D deficiency amongst adult SCD patients. MATERIALS AND METHODS A cross sectional study with appropriate control group was conducted amongst the patients of MY Hospital, Indore. The Sample included 50 cases and 50 controls. Selection of cases was done on the predefined criteria. The cases and controls were selected based on inclusion and exclusion criteria. The participants who consent to participate were included in the study. The information related to clinical, biochemical parameters were obtained from both the groups. Statistical analysis was done using SPSS software. The comparison between the groups was done using Man Whitney U test, Chi square test and correlation was obtained using Spearman’s correlation coefficient. RESULTS Results of the study showed presence of vitamin D insufficiency and deficiency amongst 92% of cases. The level of vitamin D showed significant correlation with frequency of painful crisis, blood transfusion and hospitalization. CONCLUSION It can be concluded that level of vitamin D decreases in SCD patients which can lead to complications such as painful crisis. So, vitamin D supplements can be given to such population to improve the condition of SCD patients.
Authors and Affiliations
Manoj Gupta, Dharmendra Katariya
Keywords
Related Articles
- EP ID EP604487
- DOI 10.18410/jebmh/2018/639
- Views 105
- Downloads 0
A COMPARATIVE STUDY ON PULMONARY FUNCTION TEST IN TYPE II DIABETICS AND NON-DIABETICS IN A TERTIARY CARE HOSPITAL IN KOSHI REGION (NORTHERN BIHAR), INDIA
BACKGROUND Diabetes mellitus is characterised by chronic hyperglycaemia due to defects in insulin secretion, peripheral insulin action or both which leads to alteration in the fat, proteins and carbohydrate metabolism of...
STUDY OF VARIOUS MODALITIES IN MANAGEMENT OF INCISION HERNIA REPAIR
BACKGROUND Incisional hernias are a major problem following abdominal surgery and their repairs are among the common surgeries done by a general surgeon.1 Besides the preoperative factors such as anaemia, BMI over 25 kg/...
CLINICAL, E.C.G. AND ECHOCARDIOGRAPHIC PROFILE OF PATIENTS PRESENTING WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION (STEMI) IN A TERTIARY CARE INSTITUTE AT TAMILNADU, SOUTH INDIA
BACKGROUND Coronary Artery Disease (CAD) is the leading cause of morbidity and mortality worldwide. The prevalence of CAD and the incidence of Acute Coronary Syndrome (ACS) are very high among Indians. ST Elevation Myoca...
MYOINOSITOL IN PCOS
Medical treatments for PCOS are usually aimed at improving the clinical, endocrine and metabolic effects of this disease. A combination of hormonal contraceptives, progestins, insulin sensitizing agents and statins is ef...
CHRONIC KIDNEY DISEASE PREVALENT IN SMALL VILLAGES OF NORTH COASTAL, ANDHRA PRADESH, INDIA, UDDANAM NEPHROPATHY
There are hamlets in and around Uddanam, Gunupalli, Kaviti of Srikakulam District, a North Coastal Andhra Pradesh region with high prevalence of CKD presenting clinically or sub clinically ultimately leading to high mort...