STATUS VITAMINA D KOD ŽENA SA POSTMENOPAUZALNOM OSTEOPOROZOM
Journal Title: Acta Medica Medianae - Year 2010, Vol 49, Issue 4
Abstract
Poremećaj statusa vitamina D može se manifestovati kao insuficijencija (nedostatak), nedovoljnost (deficijencija) i hipervitaminoza. Status vitamina D u organizmu određuje se merenjem nivoa 25(OH)D u serumu. Cilj našeg rada bio je da kod žena sa novodijagnostikovanom postmenopauzalnom osteoporozom odredimo status vitamina D kao i da koreliramo status vitamina D sa mineralnom koštanom gustinom (BMD) i prethodnim frakturama. Ispitivanje je obuhvatilo 58 žena sa novodijagnostikovanom postmenopauzalnom osteoporozom. Svim ispitanicama su određivani nivoi 25(OH)D kao i nivoi nespecifičnih markera koštanog metabolizma. Svim ispitanicama određivana je i koštana mineralna gustina na lumbalnoj kičmi i kuku DEXA denzitometrom. Prosečna starost ispitanica bila je 60,46±6,55 godina, prosečno trajanje menopauze 15,02±9,25 godina i prosečna vrednost 25(OH)D 46,45±14,68nmol/l. Naši rezultati su pokazali nedovoljnost vitamina D kod 89,76% ispitanica sa postmenopauzalnom osteoporozom, pozitivnu korelaciju nivoa 25(OH)D i mineralne koštane gustine (BMD) i značajno nižu početnu koncentraciju 25(OH)D kod ispitanica sa prethodnim frakturama u odnosu na one bez fraktura (37,57±13,08 vs. 51,22±17,26nmol/l; p<0,02). Naši rezultati pokazuju da nedovoljnost vitamina D kod žena sa postmenopauzalnom osteoporozom predstavlja značajan faktor rizika za nastanak fraktura, kao i faktor koji doprinosi smanjenju mineralne koštane gustine.
Authors and Affiliations
Saša Milenković, Aleksandar Dimić, Aleksandra Stanković, Ivana Aleksić, Dejan Petrović
Keywords
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