Steady State Plasma Levels of Bupropion After Administration of 3x150 Mg Extended Release Reference Tablets and Switching to 1x450 Mg Extended Release 450ER Tablets
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2012, Vol 1, Issue 2
Abstract
In order to provide patients who take 450 mg/day bupropion hydrochloride for the treatment of severe depressive disorder with a safe and convenient alternative to currently existing dose regimens, a high-dose bupropion ER tablet formulation containing 450 mg of bupropion hydrochloride was developed. The results of the single dose pharmacokinetic study demonstrated bioequivalence of the 450 mg ER tablet with three tablets of the 150 mg strength taken at once, thus confirming that the 450 mg tablet is safe and effective. In addition, the simulation of steady state bupropion plasma levels after administration of 3x150 mg bupropion ER fasting and subsequent switch to 1x450 mg bupropion ER fed confirm that even under “worst case conditions” patients who switch from 3x150 mg to 1x450 mg bupropion ER won’t experience an elevated average Cmax and hence are not exposed to an increased risk of seizures.
Authors and Affiliations
Nadine Paiement
Keywords
Related Articles
- EP ID EP201660
- DOI 10.19070/2167-910X-120005
- Views 60
- Downloads 0
Degradation Pathway for Rilpinavir Hydrochloride by Validated Stability Indicating UP-LC Method
Degradation pathway for Rilpivirine Hydrochoride is established as per ICH recommendations by validated and stability indicating reverse phase liquid chromatographic method. Rilpivirine Hydrochoride is subjected to stres...
Evaluation of Health Related Quality of Life in Patient with Oral Cavity Squamous Cell Carcinoma Receiving Chemotherapy
Objective: To evaluate impact of chemotherapy on Health Related Quality of Life (HRQOL) in patients of oral cavity squamous cell carcinoma (OCSCC) by analysis of two different treatments named Concurrent Chemo - Radiatio...
Identifying Treatment Response of Sertraline in a Teenager with Selective Mutism using Electrophysiological Neuroimaging
Background: Selective Mutism is described as the inability to verbally express oneself in anxiety provoking social situations and may result in awkward social interactions in school-aged children. In this case-report we...
Antioxidant Effects of Vitamin E in Diabetes Mellitus Type 1
In diabetes mellitus atherosclerosis is precocious, accelerated, and extensive, having influence to a large extent the secondary dislipoproteinemia to the hyper-glucemia, the lipoprotein’s glucosilation produce changes i...
Strategies for the use of SPE
Strategies for the use of SPE