Stem Cell Therapy in Diabetes Mellitus
Journal Title: Archives of Diabetes & Obesity - Year 2018, Vol 1, Issue 5
Abstract
Diabetes Mellitus is a chronic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. There is no permanent cure for Diabetes. Only way is to replace insulin producing beta-cells. Whole pancreatic transplantation and purified pancreatic islets transplantation are the answer to cure for diabetes. But scarcity of suitable donor and morbidity, high cost involved are limiting factors for pancreatic transplantation. Islet cell transplantation is less invasive procedure and safer than total pancreatic transplantation established in year 2000. Isolated islets carry less antigenic property, need less immunosuppression with fewer side effects. But major disadvantage is the life-long commitment of immune suppression which is costly and has side effects. High dose calcineurin inhibitor therapy worsens nephropathy [1]. After the islet transplantation, the clinical improvement in hyperglycemia lasts for 2 years. Subsequently, the islet function declines. Unless more cells are transplanted, euglycemia is not maintained. Patients eventually returns to full insulin dependency [2,3].
Authors and Affiliations
Poondy Gopalratnam Raman
Keywords
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- EP ID EP589325
- DOI 10.32474/ADO.2018.01.000123
- Views 32
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