STEREO SELECTIVE SYNTHESIS OF NOVEL PYRAZOLE AND COUMARIN APPENDED BRIDGED PYRANS AS ANTIMICROBIAL AGENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objectives: The aim of the present study was to synthesize a series of novel bridged pyrans as antimicrobial agents.Methods: An isomeric mixture of 3-(4-ethoxy-10-methyl-8-oxo-2-phenyl-4,8-dihydro-2H-pyrano[3',2':6,7]chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 2(a-f) and 3-(4-ethoxy-8-methyl-10-oxo-2-phenyl-4,10-dihydro-2H-pyrano[2',3':5,6]chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 3(a-f) were synthesized by the reaction of 3,3'-(7-hydroxy-4-methyl-2-oxo-2H-chromene-6,8-diyl)bis(1-phenyl-1H-pyrazole-4-carbaldehyde) 1(a-f) and ethyl alcohol in the presence of conc. H2SO4. The synthesized compounds were evaluated for their antimicrobial activity.Results: The structures of the new bridged pyran analogues 3-(4-ethoxy-10-methyl-8-oxo-2-phenyl-4,8-dihydro-2H-pyrano [3',2':6,7] chromeno [4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 2(a-f) and 3-(4-ethoxy-8-methyl-10-oxo-2-phenyl-4,10-dihydro-2H-pyrano [2',3':5,6] chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 3(a-f) were confirmed by spectral studies and elemental analysis. The compounds 2e and 3e were having-CONH2 substitution and 2f and 3f were having-CSNH2 substitutions in the pyrazole rings showed antibacterial at minimum concentrations against all the tested organisms.Conclusions: Results of the antimicrobial activity reveal that some of the synthesized compounds act as potential antimicrobial agents against different fungal and bacterial organisms.Â
Authors and Affiliations
N. Renuka, K. Ajay Kumar
Keywords
Related Articles
- EP ID EP578217
- DOI -
- Views 43
- Downloads 0
A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A COMPARATIVE STUDY
Objective: To evaluate and compare the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD) composite with common excipients used for the preparation of tablets by direct comp...
GLIMEPIRIDE FAST DISINTEGRATING TABLETS: FORMULATION, EVALUATION AND IN-VIVO DISINTEGRATION AND DYNAMIC STUDIES
Objective: The main objective of the research was to formulate directly compressible fast disintegrating tablets of glimepiride by using different super disintegrants such as crospovidone, croscarmellose sodium, sodium s...
ANTIOXIDANT AND ANTICANCER ACTIVITY OF EXTRACT AND FRACTIONS OBTAINED FROM DIOSPYROS MELANOXYLON ROXB. LEAVES AND CORRELATION WITH THEIR POLYPHENOLIC PROFILES
Objective: The current study evaluates the antioxidant and cytotoxic prospective of the leaves from Diospyros melanoxylon Roxb. (D. melanoxylon).Methods: Qualitative phytochemical analysis of the samples from D. melanoxy...
SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND RABEPRAZOLE SODIUM: METHOD DEVELOPMENT AND VALIDATION BY UV-SPECTROPHOTOMETRIC METHOD
Objectives: Study aimed for the simultaneous estimation of Famotidine and Rabeprazole sodium at 263 nm, λmax of Famotidine and 284 nm, λmax of Rabeprazole sodium.Methods: Method development and validation were done by...
DOCKING STUDY OF ALLICIN WITH SULFONYLUREA RECEPTOR 1, COMPLEX 1 AND PPARγ RECEPTOR ON INSULIN RESISTANCE
Objective: Allicin is a potential type 2 antidiabetic. Sulfonylurea receptor 1 (SUR1), nikotinamida adina dinukleotida dehydrogenase (Complex 1) and peroxisome proliferator-activated receptors gamma (PPARγ) are known as...