Steroid Sparing Symptomatic Control of Thygeson’s Superficial Punctate Keratitis (TSPK)

Apply

Steroid Sparing Symptomatic Control of Thygeson’s Superficial Punctate Keratitis (TSPK)

Journal Title: International Journal of Ophthalmology & Eye Science (IJOES) - Year 2016, Vol 4, Issue 9

Abstract

Introduction: Thygeson’s superficial punctate keratitis (TSPK) is a chronic, recurrent disorder affecting the anterior surface of the cornea. Common symptoms include photophobia, epiphora, pain and blurred vision. The management of TSPK is challenging, and long-term combined therapy is often required, namely steroids. We present a case of TSPK that was managed with a novel regenerative agent (RGTA) resulting in the symptomatic control of the condition. Methods: Observational case report. Case: A 25-year-old male patient with bilateral TSPK presented with ongoing symptoms of irritation, photophobia and foreign body sensation. Previous treatment included steroids, bandage contact lens, antibiotics and various lubricants. While steroids controlled his symptoms, he was concerned about side effects of long-term use and unwilling to persevere with treatment. He was intolerant to cyclosporin drops. As an alternative, hewasstarted on regenerative agent poly (carboxymethylglucose sulphate) known as Cacicol™. Over weeks of treatment, his symptoms were documented using a pain and photophobia score, and improved considerably. The appearance of his corneal surface also improved although epithelial defects did not completely resolve. Discussion: Literature suggests that medical interventions do not modify the natural history of TSPK and therefore treatment should be aimed at achieving symptomatic relief. During treatment with RGTA, our patient’s symptomatic relief was striking. Although, RGTA may not modify the pathogenesis of TSPK, it appears to promote healing of epithelial defects and reduce associated pain, and there is evidence to suggest it may be a useful alternative therapy to control the symptoms of TSPK.

Authors and Affiliations

Umiya Agraval

Keywords

Thygeson’s Keratitis; Therapy; Regenerative Agent; Carboxymethylglucose Sulphate.

Can Spectral-Domain Optical Coherence Tomography Findings Forecast Visual Outcome in the Case of Macular Edema?

Purpose: To evaluate the relationship between visual outcome and the photoreceptor inner segment/outer segment (IS/ OS) layer status in patients with macular edema of any etiology. Design: Cross-sectional study Patients...

To Study the Effect of Silicone Tube Intubation with and without Mitomycin C in Revision of Failed Dacryocystorhinostomy Surgery

Aims: To study the effect of silicone tube intubation with and without mitomycin c in revision of external dacryocystorhinostomy following failed dacryocystorhinostomy (DCR) surgery. Settings and Design: A Retrospective...

EP ID EP199940
DOI 10.19070/2332-290X-1600052
Views 73
Downloads 0