Stimulus Duration in a Mixed Nerve Conduction Study: Decomposing Sensory Potential

Journal Title: Turkish Journal of Neurology - Year 2020, Vol 26, Issue 4

Abstract

Objective: To decompose a part of the nerve action potential (NAP), mainly originating from large-myelinated sensory fibers, from mixed NAPs by using a stimulus with long duration during surface recordings. Materials and Methods: Median and ulnar mixed NAPs were elicited using submaximal stimulus intensities with 0.5 and 1.0-ms stimulus duration, which were adjusted to just below the threshold to activate motor fibers as detected visually through muscle twitch in hand muscles, by stimulating the median and ulnar nerves at the wrist and elbow and recording from the median and ulnar nerves at both the elbow and axilla, respectively. Healthy controls and patients with demyelinating neuropathy and/or motor conduction block were included in the study. Results: Mixed NAPs were recorded in 24 healthy subjects and three patients who had multifocal motor neuropathy (MMN), acute motor axonal neuropathy (AMAN), and ulnar entrapment neuropathy (UEN). Reference values were calculated in the healthy subjects. In patients with AMAN and MMN, mixed NAPs were normal, whereas in UEN, ulnar mixed NAPs had prolonged latencies. Conclusion: Mixed NAPs elicited by stimuli with long duration and low strength in the upper limbs can be used to detect sensory involvement at segments where motor conduction block exists and might help to classify demyelinating neuropathies.

Authors and Affiliations

Nermin Görkem Şirin, Elif Kocasoy Orhan, Sezin Alpaydın Baslo, Aysun Soysal, Kayıhan Uluç, Mehmet Barış Baslo

Keywords

Related Articles

Efficacy of Non-invasive Brain Stimulation Methods for the Treatment of Cognitive Impairment in Traumatic Brain Injury and Stroke

Cognitive impairments are pervasive among populations with traumatic brain injury and cerebral vascular accidents. Given the limited effectiveness of behavioral approaches in treating cognitive impairments, the use of no...

Seizures with Autonomic Symptoms and Sudden Unexpected Death in Epilepsy (SUDEP)

The autonomic nervous system, formerly the vegetative nervous system, is a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs. The hypoth...

Analysis of Peripapillary Retinal Nerve Fiber Layer and Macular Volume in Patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, and Healthy Controls Using Spectral Domain Optical Coherence Tomography in a Turkish Cohort

Objective: To compare the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular volume in patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and healthy controls. Mat...

Retinal Thickness Alterations in Patients with Migraine

Objective: To investigate the alterations in macula, ganglion cell complex (GCC), ganglion cell layer (GCL), macular and peripapillary retinal nerve fiber layer (pRNFL) thickness values in patients with migraine and to e...

Download PDF file
  • EP ID EP691590
  • DOI 10.4274/tnd.2020.28003
  • Views 127
  • Downloads 0

How To Cite

Nermin Görkem Şirin, Elif Kocasoy Orhan, Sezin Alpaydın Baslo, Aysun Soysal, Kayıhan Uluç, Mehmet Barış Baslo (2020). Stimulus Duration in a Mixed Nerve Conduction Study: Decomposing Sensory Potential. Turkish Journal of Neurology, 26(4), -. https://europub.co.uk/articles/-A-691590