Storage of Blood with or without Irradiation: Effect on Lipid Profile
Journal Title: International Blood Research & Reviews - Year 2016, Vol 5, Issue 4
Abstract
Aims: To observe the effect of storage on lipid profile in pre-irradiated blood and non-irradiated blood before transfusion. Study Design: Prospective study. Place and Duration of Study: Department of Biochemistry and Department of Transfusion Medicine, Pt. BD Sharma PGIMS, Rohtak, Haryana, India from April 2015 to July 2015. Methodology: Blood for transfusion (450 ml) was drawn from 60 healthy volunteer donors into CPDA-1 anticoagulant (63 ml) and stored at 2-4°C with 30 randomly selected blood bags subjected to 25 Grey gamma radiation before storage. Blood sample from each bag was analyzed at 0, 3, 7, 14 and 21 days interval for lipid profile and was compared statistically between two groups. Results: A statistically significant decrease in levels of triglycerides (TG) and very low density cholesterol (VLDL-C) while an increase in low density cholesterol (LDL-C) was observed in pre-irradiated samples as compared to non-irradiated ones in 14th day and 21st day samples. The difference in other parameters and at lesser storage durations was not found to be statistically significant. Conclusion: The blood to be transfused should be fresh, non-irradiated or stored upto a duration of two weeks after radiation especially if recipients are at increased cardiac risk. The findings need to be supported with further studies with larger sample groups.
Authors and Affiliations
Kiran Dahiya, Monica Verma, Deepika Dalal, Veena Singh Ghalaut, P. K. Sehgal, Rakesh Dhankhar, Rajesh Kumar, Sunita Kumari
Keywords
Related Articles
- EP ID EP242630
- DOI 10.9734/IBRR/2016/25942
- Views 112
- Downloads 0
Relationships between Blood Transfusion, Severity of Injury and Outcome of Severely Injured Patients Admitted to a Trauma Intensive Care Unit in Nigeria: An Observational Study
Background: Anaemia is common in critically ill trauma patients admitted into the Intensive Care Unit. The aetiology of the anaemia in trauma patients is often multi-factorial, usually resulting from the trauma event, fr...
Evaluation of Certain Blood and Biochemical Changes of Nile Catfish (Clarias gariepinus) Exposed to Mercuric Chloride with Particular Reference to Erythrocyte Morphological Anomalies
Sub-lethal toxicity of mercuric chloride (0.0002, 0.002, 0.02mg/L) in Nile catfish (Clarias gariepinus) after long-term (14 days) of exposure in the present study was investigated by measurement of some selective hematol...
Combined Closed-circuit Acute Normovolemic Hemodilution and Deliberate Hypotension in a Jehovah’s Witness: A Case Report
Aims: To enlighten both clinicians and Jehovah’s Witness patients on closed-circuit acute normovolemic hemodilution (ANH) and deliberate hypotension (DH) as safe and acceptable blood conservation strategies. Case Present...
Distribution of ABO and Rhesus Blood Groups among Voluntary Blood Donors in Enugu
Background: ABO and rhesus blood group study is very relevant to the blood transfusion services policy maker and clinicians. ABO and rhesus blood group are the most prevalent blood groups among so many other blood groups...
Gliricidia sepium Aqueous Leaf Extract Possesses Antisickling Property
Background: Extracts of leaf, flower and bark of Gliricidia sepium have been used in the treatment of patients with pathogenic bacterial infections, skin diseases, nematodes and antioxidants disturbances. We recently had...