Storage of Blood with or without Irradiation: Effect on Lipid Profile
Journal Title: International Blood Research & Reviews - Year 2016, Vol 5, Issue 4
Abstract
Aims: To observe the effect of storage on lipid profile in pre-irradiated blood and non-irradiated blood before transfusion. Study Design: Prospective study. Place and Duration of Study: Department of Biochemistry and Department of Transfusion Medicine, Pt. BD Sharma PGIMS, Rohtak, Haryana, India from April 2015 to July 2015. Methodology: Blood for transfusion (450 ml) was drawn from 60 healthy volunteer donors into CPDA-1 anticoagulant (63 ml) and stored at 2-4°C with 30 randomly selected blood bags subjected to 25 Grey gamma radiation before storage. Blood sample from each bag was analyzed at 0, 3, 7, 14 and 21 days interval for lipid profile and was compared statistically between two groups. Results: A statistically significant decrease in levels of triglycerides (TG) and very low density cholesterol (VLDL-C) while an increase in low density cholesterol (LDL-C) was observed in pre-irradiated samples as compared to non-irradiated ones in 14th day and 21st day samples. The difference in other parameters and at lesser storage durations was not found to be statistically significant. Conclusion: The blood to be transfused should be fresh, non-irradiated or stored upto a duration of two weeks after radiation especially if recipients are at increased cardiac risk. The findings need to be supported with further studies with larger sample groups.
Authors and Affiliations
Kiran Dahiya, Monica Verma, Deepika Dalal, Veena Singh Ghalaut, P. K. Sehgal, Rakesh Dhankhar, Rajesh Kumar, Sunita Kumari
Keywords
Related Articles
- EP ID EP242630
- DOI 10.9734/IBRR/2016/25942
- Views 82
- Downloads 0
An Immunohistochemical Study of PRAME Expression in Non-hodgkin’s Lymphoma
Aim: Preferentially expressed antigen of melanoma (PRAME) is a cancer-testis antigen with very low/no expression in normal tissues. PRAME is an important target for tumor immunotherapy. Prognostic and in some tumors pred...
Pattern, Determinants, and Costing Review of Send-out Tests in a Secondary Care Hospital Setting in Saudi Arabia
Background: The need for advanced laboratory tests, mostly performed at reference laboratories, increases over time. Officials have to choose between “send-out” testing or introducing such tests among their test menus, b...
In vitro Study of Antioxidant and Anticoagulant Activities of Ethanol Extract of Pandanus tectorius Leaves
Pandanus tectorius of the family Pandanaceae is a medicinal plant that grows in Nigeria. The Pandanus tectorius extract was tested for; its acute toxicity using mice and, its antioxidant activities (using DPPH spectromet...
Combined Closed-circuit Acute Normovolemic Hemodilution and Deliberate Hypotension in a Jehovah’s Witness: A Case Report
Aims: To enlighten both clinicians and Jehovah’s Witness patients on closed-circuit acute normovolemic hemodilution (ANH) and deliberate hypotension (DH) as safe and acceptable blood conservation strategies. Case Present...
Glycated Hemoglobin Evaluation by Means of Ion Exchange Chromatography and Immunoassay in Normal and Hemoglobinopathy Patients
Aims and Objectives: High performance liquid chromatography which is basically an Ion Exchange Chromatography, is the most popular as well as expensive method for glycated hemoglobin estimation but biased results have be...