Strategy to enhance solubility and dissolution of atorvastatin calcium by solid dispersion using super disintegrants
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2016, Vol 4, Issue 1
Abstract
Atorvastatin calcium (AST) is an anticholestermic agent characterize by low solubility and high permeability which corresponds to BCS class II drug. The purpose of this study was to improve the solubility and dissolution rate of poorly water soluble drug AST by solid dispersion technique using super diintegrants such as Sodium starch glycolate (SSG) and Crospovidone (CPD). Method: The solid dispersion of AST by physical mixing and solvent evaporation method were prepared using 1:1,1:3,1:5 and 1:7 ratio of drug to super disintegrants. Result: Solid dispersion were evaluated for Drug Content, Saturation solubility studies, Dissolution rate studies, Fourier Transform Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The results of FTIR demonstrate no detectable interaction between drug and super disintegrant and DSC analysis showed that sharp melting point was completely disappeared suggesting that the AST molecularly dispersed in amorphous in form. Conclusion: From solubility and dissolution data that it may concluded that through a solid dispersion prepared by solvent evaporation method in ratio 1:7 shows enhancement in solubility and dissolution but solid dispersion of drug with SSG in ratio 1:7 w/w shows better solubility and dissolution enhancement and solubility was increased almost 4 folds from this dispersion. Tablets were formulated containing optimised solid dispersion and compared with marketed tablet.
Authors and Affiliations
Vilas P Bharati
Keywords
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