STREPTOMYCES CELLULOSAE VJDS-1, A PROMISING SOURCE FOR POTENTIAL BIOACTIVE COMPOUNDS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objectives: The aim of the present study was to isolate, identify and analyze the phylogenetic characteristics of the potent actinobacterial strain VJDS-1 with antagonistic activities isolated from Mangrove ecosystems of Nizampatnam, Guntur Dist, A.P., India.Methods: Soil samples collected were pre treated with calcium carbonate and used for isolation of potent actinobacterial strain designated as VJDS-1. Identification of the strain was carried out by studying the micro morphological, cultural, biochemical and physiological methods. The Phylogenetic study of the strain was carried out by employing 16S rDNA sequence based analysis. Phylogenetic tree was constructed using the MEGA (Molecular Evolutionary Genetic Analysis) software version 6.Results: The potent actinobacterial strain was identified as Streptomyces cellulosae VJDS-1 and the bioactive metabolites produced by the strain inhibited Gram positive bacteria (Staphylococcus aureus, Bacillus megaterium), Gram negative bacteria (Xanthomonas campestris, Proteus vulgaris, Pseudomonas aeruginosa and Escherichia coli) and fungi (Aspergillus niger, Botrytis cinerea, Fusarium solani F. oxysporum and Candida albicans).Conclusion: The results of the experiment showed that the crude ethyl acetate extract of Streptomyces cellulosae VJDS-1 showed significant antimicrobial potential hence it can be used for isolation of compounds with pharmaceutical importance.Â
Authors and Affiliations
Mani Deepa Indupalli, Vijayalakshmi Muvva, Rajesh Kumar Munaganti
Keywords
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