STRESS & AUTOIMMUNE DISEASES
Journal Title: The Journal of Middle East and North Africa Sciences - Year 2016, Vol 2, Issue 2
Abstract
Incidences of autoimmune diseases are rising; the numbers of cases are tripled over the last few decades. There are more than eighty illnesses caused by autoimmunity. It has been estimated that autoimmune diseases are among the ten leading causes of death among women in all age groups up to 65 years. The etiology of autoimmune diseases is multifactorial: Genetic, hormonal, environmental, immunological factors, together with host susceptibility are all considered important in their development. The cause of this worldwide epidemic lies primarily in our environment and the toxic world in which we live, as various stressors have been implicated in the induction and perpetuation of many autoimmune diseases. Various stressors including physical, chemical, biological, and psychological have been shown to be responsible for this growing epidemic. Understanding the pathogenic modes of actions of various stressors e.g. molecular mimicry, role of cytokines, Toll-like receptors signaling pathways, role of stress proteins (heat shock proteins), role of reactive species, in addition to neuroendocrine immune systems interactions foster the advent in targeted therapeutic era. New strategies have been introduced and are being studied to overcome effects of oxidative stress at the cellular level for subsequent use as new therapies for autoimmune diseases e.g. targeting intracellular signaling pathways for various proinflammatory cytokines, DNA vaccines, anti-inflammatory neuropeptides, and more. The better understanding of these etiopathogenetic mechanisms can move us from the era of controlling or treating autoimmune diseases to a new era of preventing these diseases.
Authors and Affiliations
Hala L. Fayed
Keywords
Related Articles
- EP ID EP208146
- DOI -
- Views 138
- Downloads 0
Proximate and Mineral Composition of Some Commercially Important Fishes in Jebl Awlia reservoir, Sudan
The proximate and mineral composition of the flesh of six commercially important fish species (Lates niloticus, Bagrus bayad, Oreochromis niloticus, Synodontis schall, Labeo niloticus and Hydrocynus froskalii) from Jebl...
Assessing the Success of School Cluster Zoning System in Senior Secondary Schools of Adamawa State, Nigeria
This study assessed the success of school cluster zoning System in Senior Secondary Schools in Adamawa State. Education systems in most states in Nigeria are facing severe economic pressures which hinder achievement of b...
Protecting and Preserving East Sea’s Environment According to Regulations of International Law in the Integration Context
Protecting and preserving East Sea’s environment according to regulations of international law nowadays urgent problem, it’s many scientists in the world interested and studied. In this article, the author will analyze d...
In Vitro Antibacterial Activity of Adenia Cissampeloides Plant Extracts on Bacteria Isolated from Fishes Recovered from Uwana River, Ebonyi State, Nigeria
Adenia Cissampeloides, a Pesticidal plant has dynamic active ingredients which cause physiological destruction in fishes including Clarias gariepinus. Majority of these Pesticidal plants contain medicinal values. In this...
Knowledge of Prostate Cancer Screening among Jordanian Men in Amman
Background: Prostate cancer has become a major public health concern for primarily affecting older men. It is the most commonly diagnosed cancer in men and ranked second as the cause of cancer-related death. The main aim...