Structural Bioinformatics: Computational Software and Databases for the Evaluation of Protein Structure
Journal Title: RADS Journal of Biological Research and Applied Science - Year 2018, Vol 9, Issue 2
Abstract
Databases are the computerized platform where information is stored and can be retrieved easily by public users. Biological databases are the repositories of biological data. These biological data libraries contain facts and figures related to various disciplines of research including genomics, proteomics, microarray technology, metabolomics and phylogenetics. By using biological databases, a broad collection of essential biological information can be exploited ranging from function, structure and localization of gene, clinical consequences of mutation to similarity index among biological sequences and structures. Nowadays, different kinds of biological databases are available on the web. The present write up focuses on biological databases and bioinformatics tools for protein structure analysis. This review also aims to elaborate the searching schemes, available in different structural databases. The wide variety of different levels and types of information content related to 3D protein structures are available on web-based databases. Regarding the biological functions and 3D structures of various proteins, these databases provide a huge range of useful links, schematic diagrams as well as strategies for detailed analysis of proteins and other macromolecules structures. 3D structural illustration of proteins stored in structural databases is determined and visualized by X-ray crystallography, electron microscopy and NMR spectroscopy. On regular basis, a large number of protein structures are submitted by structural biologists, updated and curated by subject experts. Most familiar biological databases that store 3D protein and other macromolecules structures include, PDB, 3D Genomics, CATH, & SCOP. These databases contain valuable information of overall protein structures, domains and motif structures, protein-protein complex systems and complex of protein with other biomolecules.
Authors and Affiliations
Ayisha Amanullah, Suad Naheed
Keywords
Related Articles
- EP ID EP545257
- DOI -
- Views 224
- Downloads 0
Ethnobotanical Profile of Weed Flora of District Charsadda, Khyber Pakhtunkhwa
District Charsadda is a very important center of plant biodiversity in the central plain of Peshawar valley, Pakistan. The present study was carried out during March 2015 to April 2016 to investigate the ethnobotanical p...
A Simplistic Screening Assay of Antimicrobial Compounds and Enzymatic Activity from Local Soil Microbes
Antibiotics production is the most emerging field worldwide with a constant need for the new ones to fight the microbial resistance. In this context, the research was pursued to isolate, characterize and screen for promi...
Identification and Antibiotic Susceptibility Testing of ESBL producing Klebsiella strains by Phenotypic methods
Multi drug resistance has now become a worldwide therapeutic challenge due to the widespread use of broad spectrum antibiotics. Klebsiella species have significant importance in clinical field as they cause various infec...
Citrus Fruit Peels in Combating Various Foodborne Pathogens
Foodborne diseases are the world's main problem in a society nowadays; many phytochemicals are of great interest to scientists. Herbal medicines can be used to treat many infectious diseases. In our study, we focus on sc...
Conocarpus Mediated Improvement in Photosynthetic Pigments of Cicer arietinum Growing Under Copper Stress
Present work was planned to investigate the improvement in photosynthetic pigments of Cicer arietinum by Conocarpus lancifolius growing under copper stress. Conocarpus lancifolius was chosen as a biosorbent because it is...