Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 4
Abstract
Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD). Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package. Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected). Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.
Authors and Affiliations
Javier Olazarán, Pablo García-Polo, Daniel García-Frank, Alicia Quirós, Juan Antonio Hernández-Tamames, Carmen Acedo, Juan Álvarez-Linera, Ana Frank
Keywords
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- EP ID EP340160
- DOI 10.9734/BJMMR/2016/24034
- Views 45
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