Structural Correlates of Depressive Symptoms in Prodromal Alzheimer’s Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 4
Abstract
Background/Aims: We conducted a cross-sectional study to investigate the structural magnetic resonance imaging correlates of depressive symptoms at the initial clinical stages of Alzheimer’s disease (AD). Methods: Subjects aged 65 or more were categorized as prodromal AD (n=18), mild AD (n=35), or normal cognition (n=76). Depressive symptoms were measured by means of the 15-item abridged version of the Geriatric Depression Scale. Potential gray matter correlates of depressive symptoms were analyzed using the Statistical Parametric Mapping software package. Results: Significant results were obtained in the prodromal AD group only. In that group, depressive symptoms were related to atrophy in the left precentral gyrus (Brodmann area 6) (p≤0.01, FWE corrected). Conclusion: Our results, added to the existing literature, suggest that dysfunction in left-sided, cognitively and functionally salient, cortical regions along with relative preservation of deficit awareness, provided by the right hemisphere, explain depressive symptoms in the initial clinical stages of AD.
Authors and Affiliations
Javier Olazarán, Pablo García-Polo, Daniel García-Frank, Alicia Quirós, Juan Antonio Hernández-Tamames, Carmen Acedo, Juan Álvarez-Linera, Ana Frank
Keywords
Related Articles
- EP ID EP340160
- DOI 10.9734/BJMMR/2016/24034
- Views 74
- Downloads 0
An Interventional Study Comparing the Memory Retention of Verbal & Pictorial Materials among MMMC Students
Aims: To compare the effectiveness of pictorial against verbal materials in memory retention among medical students. Study Design: Crossover randomized controlled trial. Place and Duration of Study: This study was conduc...
Audiometric and Tympanometric Assessment in Patients with Oral Submucous Fibrosis
Background: Oral submucous fibrosis (OSMF) is regarded as a potentially malignant condition. It is characterized by a mucosal rigidity of variable intensity because of the fibroelastic changes of the juxta epithelial lay...
Chronic Use of Hormonal Contraceptives and Its Impact on Cardiovascular Risk
Aims: The purpose of the study was to observe if hormonal contraceptive use increases CV risk in women from Ghana through increasing CV RF. Study Design: The study was longitudinal and purposive random sampling was done....
Positive Correlation of Thyroid Gland Volume with Isthmus Dimensions and with Anthropometric Parameters through a Cross Sectional Study on Karachi Population
Objective: Diverse variation in normal thyroid gland volume (TGV) among populations is mainly due to age, gender, anthropometric parameters and genetic factors. This study was carried out to determine the correlation be...
Effect of Muscle Energy Technique on Pain Perception and Functional Disability of Women with Postnatal Low Back Pain
Aims: To determine the effect of muscle energy technique (MET) on postnatal low back pain. Place and Duration of Study: Department of obstetrics and gynecology, Ain Shams University Hospital, and Outpatient Clinic of Fac...