Structural Studies and Biological Activity of Thiobarbituric Acid Complexes
Journal Title: Journal of Pharmaceutical and Medicinal Chemistry - Year 2018, Vol 4, Issue 2
Abstract
Twelve complexes derived from thiobarbituric acid with Cu, Zn, Co, Fe, Cd and Ni have been prepared and analyzed in the mole ratios 1:1,1:2, 1:3 and 1:4 (M : L). They were characterized by elemental analysis, UV-Vis, IR, 1H-NMR, ESR for Copper complexes, Magnetic Susceptibility and Thermal Analysis (TGA, DTA). The biological activities of thiobarbituric acid and its complexes which are tested against staphylococcus aureus (Gram positive) bacteria, Esherichia coli (Gram negative) bacteria and Candida albicans fungi. The results showed that some of the tested compounds have a well considerable activity against the tested microorganisms. The data of MIC showed that Cu (II) complexes were the most effective antibacterial and antifungal agents compared to the other complexes.
Authors and Affiliations
Mamdouh S. Masoud
Keywords
Related Articles
- EP ID EP564999
- DOI 10.21088/jpmc.2395.6615.4218.3
- Views 101
- Downloads 0
Analytical Method for the Simultaneous Estimation of Sitagliptin and Simvastatin using RP-HPLC
A novel, rapid, precise and accurate high performance liquid chromatographic method was developed and validated for the simultaneous determination of Sitagliptin phosphate and Simvastatin in bulk drug and pharmaceutical...
A Review on Oral Hypoglycemic Drugs
Globally, an estimated 422 million adults are living with diabetes mellitus, according to the latest 2016 data from the World Health Organization. Diabetes is a group of disorder characterized by high blood glucose level...
Bioinorganic Chemistry of Metal Chitosans and Nucleic Acids Complexes
Bacterial samples were collected from consecutive diabetic patients with foot wounds at the Vascular Surgery Unit and the Diabetic Foot Unit of Alexandria Main University Hospital, Faculty of Medicine, Alexandria Univers...
Structural Studies and Biological Activity of Thiobarbituric Acid Complexes
Twelve complexes derived from thiobarbituric acid with Cu, Zn, Co, Fe, Cd and Ni have been prepared and analyzed in the mole ratios 1:1,1:2, 1:3 and 1:4 (M : L). They were characterized by elemental analysis, UV-Vis, IR,...
RP-HPLC Method Development and Validation for the Estimation of Imipramine Hydrochloride in Pharmaceutical Dosage Form
A simple, rapid, precise and accurate RPHPLC method has been developed and validated for estimation of Imipramine Hydrochloride (IMH) in pharmaceutical dosage form. The method is carried out on Agilent C18 (25 cm x 4.6 m...