Studies of phthalates pigeon scabious (Scabiosa columbaria L.)
Journal Title: Фармацевтичний журнал - Year 2016, Vol 1, Issue 1
Abstract
Scabiosa columbaria L. (Pigeon scabious) – a perennial herb of the Teasel family (Dipsacaceae), which occurs in the Carpathian region. The plant is used in folk medicine as a antitussive remedy for acute respiratory diseases and in the treatment of scabs, from which is said to have happened its Latin name. Information about the chemical composition of plants is quite limited, although it is known that it contains tannins, saponins and bitter constituens. The aim of its study is investigation of chemical composition aerial part of plant and identify substances that may have antiparasitic and repellent properties. For this purpose herbs were collected during flowering, dried, milled, defatted and extracted with ethanol. After distilling off the ethanol, aqueous residue was extracted with ethyl acetate. The resulting residue was separated on a polyamide column. Qualitative and quantitative composition of the fractions were examined by gas chromatography-mass-spectrometry. The ethyl acetate extract on a polyamide column was separated on the three fractions, which were different solubility in ethanol. Using gas chromatography-mass-spectrometry was found that fractions of the ethyl acetate extract scabiosa pigeon predominate esters of higher fatty acids (such as palmitic) and phthalic acid. As major components identified diisooctylphtalate, bis-(ethylhexyl)phthalate and dibutylphthalate. In particular, in the fractions N 3 the two ethers of phthalic acid were about 90% (dibutylphthalate and bis-(ethylhexyl)phthalate) of the total weight of fraction. In fractions N 1 and N 2 phthalate content was somewhat lower – 72.18% and 34.54%, respectively. Based on the expressed anti-parasitic action of these substances can be assumed that the data of folk medicine about anti-parasitic action scabiosa pigeon are not motiveless, but require further testing.
Authors and Affiliations
R. B. Vinnitska
Keywords
Related Articles
- EP ID EP561436
- DOI -
- Views 69
- Downloads 0
Anatomical structure of the leaves and flowers оf primrose (Primula veris L.)
Primula (Primula veris L., Primula officinalis Hill.) is a perennial herbaceous plant with a short rhizome and threadlike roots. The leaves are radical, oblong-ovate, wrinkled. The flowers are regular, bright yellow, loc...
Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols
Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range...
Theoretical and experimental substantiation of the composition of the gel with the anti-inflammatory and local anesthetic action for application in sports medicine
The use of compounds of the natural origin, in particular standardized substances of propolis in combination with local anesthetics in the composition of soft dosage forms results in more expressed anti-inflammatory and...
An influence of the cream with cerium dioxide nanoparticles on some vital signs of rats in the setting of a topical application in a chronic experiment
Melanoma and non-melanoma cancers are global healthcare problems nowadays. Ultraviolet (UV) radiation exposure is one of the risk factors of development of these pathologies. An introduction of sunscreen creams with ceri...
Histological study of the influence of antidiabetic plant collection on pancreatic tissue in rats with diabetes mellitus, which is induced by dexamethasone
Diabetes mellitus is a global problem today, because there is a sharp increase the number of patients in the world each year. Severe complications of diabetes are very dangerous because it can lead to disability of patie...