STUDIES ON COMBINED TOXICITY OF PENDIMETHALIN AND CADMIUM CHLORIDE WITH AMELIORATIVE EFFECT OF VITAMIN E-SELENIUM AND TURMERIC IN MALE ALBINO RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The present investigation was undertaken to study the pathology of pendimethalin and cadmium chloride and to evaluate the different concentration were used as ameliorative agents to reduce theoxidative damage caused by free redicals genreted by toxic pollutants at molecular levels. A total of 5 groups each of 12 rats were formed apart from control group. 2 groups of heavy metal and pesticide and 3 group of ameliorative oxidant in varying concentrations were formed Group T2 was given standard ration along with combination of cadmium chloride at 500 ppm with pendimethalin (38.7%) at 1000 ppm/kg feed, Group T3 was given cadmium chloride at 100ppm/kg feed and P pendimethalin (38.7%) at 1000 ppm/kg feed with standard ration, Group T4 was fed with the combination of cadmium chloride at 50 ppm/kg of feed with pendimethalin at 1000 ppm/kg of feed and alpha tocopherol-selenium at 18 ppm/kg of feed. Lastly group T5 and T6 were given turmeric at 0.5%and 1% concentrations respectively along with the combination of cadmium chloride at 50 ppm with pendimethalin (38.7%) at 1000ppm and alpha tocopherol-selenium at18ppm/kg of feed. During the toxicity studies observation like effect on CNS, effect on locomotors system recorded on the days 0, 7, 14, 21 and 28 of experiment.
Authors and Affiliations
Supriya Shukla
Keywords
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